Geranylgeranyl diphosphate reductase

Geranylgeranyl diphosphate reductase (EC 1.3.1.83, geranylgeranyl reductase, CHL P) is an enzyme with systematic name geranylgeranyl-diphosphate:NADP⁺ oxidoreductase.^[1]^[2]^[3] This enzyme catalises the following chemical reaction

phytyl diphosphate + 3 NADP⁺

\rightleftharpoons

geranylgeranyl diphosphate + 3 NADPH + 3 H⁺

This enzyme also acts on geranylgeranyl-chlorophyll a.

References

↑ Soll, J.; Schultz, G.; Rudiger, W.; Benz, J. (1983). "Hydrogenation of geranylgeraniol : two pathways exist in spinach chloroplasts". Plant Physiol. 71 (4): 849–854. doi:10.1104/pp.71.4.849. PMC 1066133. PMID 16662918.
↑ Tanaka, R.; Oster, U.; Kruse, E.; Rudiger, W.; Grimm, B. (1999). "Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductas". Plant Physiol. 120 (3): 695–704. doi:10.1104/pp.120.3.695. PMC 59307. PMID 10398704.
↑ Keller, Y.; Bouvier, F.; d'Harlingue, A.; Camara, B. (1998). "Metabolic compartmentation of plastid prenyllipid biosynthesis—evidence for the involvement of a multifunctional geranylgeranyl reductase". Eur. J. Biochem. 251 (1-2): 413–417. doi:10.1046/j.1432-1327.1998.2510413.x. PMID 9492312.

Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase

1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD

1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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