Daniela Rhodes

Daniela Rhodes

Daniela Rhodes at the Laboratory of Molecular Biology
Institutions
Alma mater University of Cambridge
Thesis The helical periodicity of DNA in solution and in chromatin (1982)
Doctoral advisor Aaron Klug[2]
Notable awards FRS (2007)[3]
Website
www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/daniela-rhodes/

Daniela Rhodes FRS[3] is a distinguished structural and molecular biologist. She was a senior scientist at the Laboratory of Molecular Biology in Cambridge, England,[4] where she worked, and later studied for her Ph.D[5] under the supervision of Nobel laureate Aaron Klug. Continuing her work under the tutelage of Aaron Klug at Cambridge, she was appointed Group Leader in 1983, obtained tenure in 1987 and was promoted to Senior Scientist in 1994 (equivalent to Full Professor). Subsequently, she served as Director of Studies between 2003-2006. She has also been Visiting Professor at both “La Sapienza” in Rome, Italy and the Rockefeller University in NY, USA.[6][7][8][9][10]

Career and research

Daniela Rhodes has made many fundamental contributions to understanding the structure and function of nucleic acids and their biologically important interactions with many different proteins. Her work combines biochemical analyses with direct structural determination. She determined the structures of a number of important protein-DNA complexes involved in transcription, such as zinc-fingers and nuclear hormone receptors. She has provided some of the first structural information on telomeric proteins, such as yeast Rap1p and human TRF1 and TRF2 and their complexes with DNA. Throughout her career she has made many contributions to the understanding of chromatin structure and function. She was involved in determining the structure of the nucleosome core particle, has worked on transcriptionally active chromatin and more recently on the higher order 30nm structure of chromatin.[4] Her research continues to focus on understanding how the structure of chromatin is involved in transcriptional regulation and how telomeres are involved in preserving chromosome integrity.[11]

She joined the School of Biological Sciences at Nanyang Technological University (NTU), in Singapore, as professor in September 2011[12] and was additionally appointed professor at the Lee Kong Chian School of Medicine in September 2012.[13] In April 2014 she was appointed Director of the newly formed Nanyang Institute of Structural Biology.

Awards and honours

References

  1. ↑ "Emeritus Scientist: Daniela Rhodes". Laboratory of Molecular Biology. Archived from the original on 2015-12-08.
  2. ↑ Rhodes, D. (2002). "Climbing mountains: A profile of Max Perutz 1914-2002: a life in science". EMBO reports. 3 (5): 393–395. doi:10.1093/embo-reports/kvf103. ISSN 1469-221X.
  3. 1 2 3 "Professor Daniela Rhodes FRS". London: Royal Society. Archived from the original on 2015-11-17.
  4. 1 2 "International Conference - Speakers - Daniela Rhodes". SET-Routes. 2008-04-01. Retrieved 2014-01-02.
  5. ↑ Rhodes, Daniela (1982). The helical periodicity of DNA in solution and in chromatin. (PhD thesis). University of Cambridge. OCLC 556524059.
  6. ↑ "Analysis of sequence-specific DNA-binging proteins", Protein function: a practical approach, Editor Thomas E. Creighton, Oxford University Press, 1997, ISBN 978-0-19-963615-0
  7. ↑ "The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression", Structural biology and functional genomics, Editors E. Morton Bradbury, Sándor Pongor, Springer, 1999, ISBN 978-0-7923-5781-0
  8. ↑ "Telomeric DNA Recoginition", RNA biochemistry and biotechnology, Volume 1998, Editors Jan Barciszewski, Brian Frederic Carl Clark, Springer, 1999, ISBN 978-0-7923-5861-9
  9. ↑ "Structure of the 30nm Chromatin Fibre and the Regulation of Its Compaction" "Daniela Rhodes, PhD — Biochemistry and Biophysics". University of North Carolina School of Medicine. 2008-04-22. Retrieved 2014-01-02.
  10. ↑ Daniela Rhodes's profile at Scientific Commons
  11. ↑ LMB Web-page
  12. ↑ "Academic Profile: Professor Daniela Rhodes". Nanyang Technological University. 2009-08-04. Retrieved 2014-01-02.
  13. ↑ "Academic Profile: Professor Daniela Rhodes". LKC School of Medicine. 2009-08-04. Retrieved 2014-04-03.
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