Coenzyme F420-0:L-glutamate ligase

Coenzyme F420-0:L-glutamate ligase (EC 6.3.2.31, CofE-AF, MJ0768, CofE) is an enzyme with systematic name L-glutamate:coenzyme F420-0 ligase (GDP-forming).^[1]^[2] This enzyme catalyses the following chemical reaction

GTP + coenzyme F420-0 + L-glutamate

\rightleftharpoons

GDP + phosphate + coenzyme F420-1

This protein catalyses the successive addition of two glutamate residues to cofactor F420 by two distinct and independent reactions.

References

↑ Li, H.; Graupner, M.; Xu, H.; White, R.H. (2003). "CofE catalyzes the addition of two glutamates to F₄₂₀-0 in F₄₂₀ coenzyme biosynthesis in Methanococcus jannaschii". Biochemistry. 42: 9771–9778. doi:10.1021/bi034779b. PMID 12911320.
↑ Nocek, B.; Evdokimova, E.; Proudfoot, M.; Kudritska, M.; Grochowski, L.L.; White, R.H.; Savchenko, A.; Yakunin, A.F.; Edwards, A.; Joachimiak, A. (2007). "Structure of an amide bond forming F₄₂₀:γ-glutamyl ligase from Archaeoglobus fulgidus — a member of a new family of non-ribosomal peptide synthases". J. Mol. Biol. 372: 456–469. doi:10.1016/j.jmb.2007.06.063. PMID 17669425.

Enzymes: CO CS and CN ligases (EC 6.1-6.3)

6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine

6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase

6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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