Carboxybiotin decarboxylase

Carboxybiotin decarboxylase (EC 4.3.99.2, MadB, carboxybiotin protein decarboxylase) is an enzyme with systematic name carboxybiotinyl-(protein) carboxy-lyase.^[1]^[2] This enzyme catalyses the following chemical reaction

a carboxybiotinyl-[protein] + n Na⁺_in + H⁺_out

\rightleftharpoons

CO₂ + a biotinyl-[protein] + n Na⁺_out (n = 1--2)

This enzyme is an integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra.

References

↑ Berg, M.; Hilbi, H.; Dimroth, P. (1997). "Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na⁺ pump and evidence for their function". Eur. J. Biochem. 245: 103–115. doi:10.1111/j.1432-1033.1997.00103.x. PMID 9128730.
↑ Dimroth, P.; Hilbi, H. (1997). "Enzymic and genetic basis for bacterial growth on malonate". Mol. Microbiol. 25: 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.

Carbon-nitrogen lyases (EC 4.3)

4.3.1: ammonia-lyases	Histidine ammonia-lyase Formiminotransferase cyclodeaminase Serine dehydratase

4.3.2: amidine-lyases	Argininosuccinate lyase Adenylosuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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