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Parasites are thrown at players by The Nightmare while fighting her. After the Parasite has grown, it will burst out of the player, damaging them and proceeding to heal The Nightmare until killed. Sanfew serum and Relicym's balm will weaken the parasite.

If players don't weaken the parasite inside them, the damage they receive when it bursts out of them will be added onto the parasite's overall health.