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  1. 1. Healing Properties
    1. 1.1. Brain Health
    2. 1.2. Antioxidant
    3. 1.3. Anti-glycation
    4. 1.4. Microglial Neuroprotective
  2. 2. Disease / Symptom Treatment
    1. 2.1. Neurodegenerative Diseases
      1. 2.1.1. Alzheimer’s Disease


Healing Properties

Brain Health


Free radical scavenging.


Glycation is associated with several neurodegenerative disorders, including Alzheimer’s disease (AD, where it potentiates the aggregation and toxicity of proteins such as β-amyloid (Aβ).[1]

Glycation is a process that interferes with the molecular and cellular functioning of the entire body. It involves the release of highly oxidizing side-products such as hydrogen peroxide.

  • Damage by glycation results in stiffening of the collagen in the blood vessel walls, leading to high blood pressure, especially in diabetes.
  • Glycations also cause weakening of the collagen in the blood vessel walls, which may lead to micro- or macro-aneurisms; this may cause strokes if in the brain.
  • Parts of the body most at risk to the affects of glycation are: Long-lived cells (such as nerves and different types of brain cell), long-lasting proteins (Cells such as the retina cells in the eyes; crystallins of the lens and cornea), and DNA may accumulate substantial damage over time.
  • Red blood cells have a consistent lifespan of 120 days and are easily accessible for measurement of glycation.

Microglial Neuroprotective

Polyphenol & anthocyanin-enriched extracts of blackberry help protect the brain’s microglia.[1:1]

Microglia are a type of glial cell located throughout the brain and spinal cord. Microglia account for 10–15% of all cells found within the brain. Microglia act as the first and main form of active immune defense in the central nervous system.

  • Decreased cytotoxicity in microglia.[1:2]
  • Prevents Ameloydβeta fibrillation[1:3]

Disease / Symptom Treatment

Neurodegenerative Diseases

Alzheimer’s Disease

  1. Title: Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects
    Publication: International Journal of Moleculary Sciences
    Date: Feb 2018
    Study Type: Animal Study, Commentary, Human Study: In Vitro - In Vivo - In Silico, Human: Case Report, Meta Analysis, Review
    Author(s): Hang Ma, Shelby L. Johnson, Weixi Liu, Nicholas A. DaSilva, Susan Meschwitz, Joel A. Dain, and Navindra P. Seeram
    Institutions: Wuyi University, Wuyishan, Nanping, Fujian, China; International Healthcare Innovation Institute (Jiangmen), Jiangmen, Guangdong, China; University of Rhode Island, Kingston, Rhode Island, USA; Salve Regina University, Newport, Rhode Island, USA
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