History of 19th-Century Oregon [[Timeline, with relevant images next to each date.]] 1805 [[Two men stand at the edge of a cliff. One has a walking staff.]] Arrival of Lewis & Clark 1825 Early settlers arrive 1841 Oregon trail established 1843 Larger western migration begins 1848 [[A horse is pulling a covered wagon. A gun peeks out the back.]] Huge wave of 500,000+ settlers arrives from Missouri. Largely children and adolescents, most bring nothing but cartloads of bullets for hunting. 1849 [[Two men with rifles aim at something.]] Overhunting begins to devastate ecosystem Dysentery epidemic 1850 [[Tombstones. Bodies.]] Shooting deaths skyrocket Typhoid epidemic Measles epidemic Cholera epidemic 1851 All mammals larger than squirrels wiped out by overhunting. Massive famine 1852 [[Sun low over a land, devoid of life. Scattered remains of corpses.]] Last survivors flee Oregon territory abandoned {{Title text: A century later, the harrowing flight of the survivors from Oregon was dramatized in a popular video game.}}