IUPAC name
725247-18-7 YesY
3D model (Jmol) Interactive image
ChemSpider 5293979 N
ECHA InfoCard 100.163.130
PubChem 6918788
Molar mass 596.424949
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

XCT790 is a potent and selective inverse agonist ligand of the estrogen-related receptor alpha.[1] Independent of its inhibition of ERRα, XCT790 is a potent mitochondrial electron transport chain uncoupler. [2]

Mitochondrial electron transport chain uncoupling effect

XCT790 has been shown to uncouple oxygen consumption from ATP production in mitochondria at very low, nanomolar-range doses independently of ERRα expression. Its effects are similar to proton ionophores such as FCCP, which disrupt mitochondrial transmembrane electrochemical gradients. This uncoupling leads to a fast drop in ATP production and, consequently, a prompt activation of AMPK.[2]


  1. Busch BB, Stevens WC Jr, Martin R, Ordentlich P, Zhou S, Sapp DW, Horlick RA, Mohan R; Stevens (November 2004). "Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha". J. Med. Chem. 47 (23): 5593–6. doi:10.1021/jm049334f. PMID 15509154.
  2. 1 2 Eskiocak B; Aktar Ali; White MA (July 7, 2014). "The estrogen-related receptor α inverse agonist XCT 790 is a nanomolar mitochondrial uncoupler". Biochemistry. 53 (29): 4839–4846. doi:10.1021/bi500737n. PMID 24999922.

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