Vitamin E deficiency

Vitamin E deficiency
Classification and external resources
Specialty endocrinology
ICD-10 E56.0
ICD-9-CM 269.1
DiseasesDB 13950
eMedicine article/126187
MeSH D014811

Vitamin E deficiency or hypovitaminosis E is a deficiency of vitamin E. It causes nerve problems due to poor conduction of electrical impulses along nerves due to changes in nerve membrane structure and function.

Signs and symptoms

Signs of vitamin E deficiency include the following:

There is also some laboratory evidence that vitamin E deficiency can cause male infertility.[1]


Vitamin E deficiency is rare and is almost never caused by a poor diet.[1] Instead, there are three specific situations when a vitamin E deficiency is likely to occur:[5]



The treatment is some form of Vitamin E supplementation.

Aggressive vitamin E replacement therapy has been shown to either prevent, halt or improve visual abnormalities.

See also


  1. 1 2 3 4 5 Brigelius-Flohé R, Traber MG (July 1999). "Vitamin E: function and metabolism". FASEB J. 13 (10): 1145–55. PMID 10385606.
  2. 1 2 Office of Dietary Supplements. "Vitamin E Professional Fact Sheet". National Institutes of Health. Retrieved 14 August 2010.
  3. 1 2 Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000.
  4. 1 2 Kowdley KV, Mason JB, Meydani SN, Cornwall S, Grand RJ (June 1992). "Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption". Gastroenterology. 102 (6): 2139–42. PMID 1587435.
  5. Traber MG, Sies H (1996). "Vitamin E in humans: demand and delivery". Annu. Rev. Nutr. 16: 321–47. doi:10.1146/ PMID 8839930.
  6. Manor D, Morley S (2007). "The alpha-tocopherol transfer protein". Vitam. Horm. 76: 45–65. doi:10.1016/S0083-6729(07)76003-X. PMID 17628171.
  7. Muller DP, Lloyd JK, Wolff OH (1983). "Vitamin E and neurological function: abetalipoproteinaemia and other disorders of fat absorption". Ciba Found. Symp. 101: 106–21. doi:10.1002/9780470720820.ch8. PMID 6557902.
  8. Page, C.; Blake, D.; Winyard, P.G. (1995). Immunopharmacology of Free Radical Species. Elsevier Science. p. 136. ISBN 9780080534541. Retrieved 12 April 2015.
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