Amino acid transporter

Transmembrane amino acid transporter protein
Symbol Aa_trans
Pfam PF01490
InterPro IPR013057
TCDB 2.A.18

An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.


There are several families that function in amino acid transport, some of these include:

Solute carrier family examples


Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.[13]

Human proteins containing this domain

ATA2; SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6;

See also


  1. Kanai Y, Hediger MA (2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflugers Arch. 447 (5): 469–479. doi:10.1007/s00424-003-1146-4. PMID 14530974.
  2. Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch. 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309.
  3. Singh SK, Piscitelli CL, Yamashita A, Gouaux E (2008). "A competitive inhibitor traps LeuT in an open-to-out conformation". Science. 322 (5908): 1655–1661. doi:10.1126/science.1166777. PMID 19074341.
  4. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch. 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310.
  5. Daniel H, Kottra G (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflugers Arch. 447 (5): 610–618. doi:10.1007/s00424-003-1101-4. PMID 12905028.
  6. Reimer RJ, Edwards RH (2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflugers Arch. 447 (5): 629–635. doi:10.1007/s00424-003-1087-y. PMID 12811560.
  7. Eiden LE, Schafer MK, Weihe E, Schutz B (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflugers Arch. 447 (5): 636–640. doi:10.1007/s00424-003-1100-5. PMID 12827358.
  8. Palmieri F (2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflugers Arch. 447 (5): 689–709. doi:10.1007/s00424-003-1099-7. PMID 14598172.
  9. Mount DB, Romero MF (2004). "The SLC26 gene family of multifunctional anion exchangers". Pflugers Arch. 447 (5): 710–721. doi:10.1007/s00424-003-1090-3. PMID 12759755.
  10. Gasnier B (2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflugers Arch. 447 (5): 752–755. doi:10.1007/s00424-003-1091-2. PMID 12750892.
  11. Boll M, Daniel H, Gasnier B (2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family". Pflugers Arch. 447 (5): 776–779. doi:10.1007/s00424-003-1073-4. PMID 12748860.
  12. Mackenzie B, Erickson JD (2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflugers Arch. 447 (5): 784–795. doi:10.1007/s00424-003-1117-9. PMID 12845534.
  13. [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003
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