VAMP1

Identifiers

VAMP1, SPAX1, SYB1, VAMP-1, vesicle associated membrane protein 1

External IDs

MGI: 1313276 HomoloGene: 40678 GeneCards: VAMP1

Gene ontology
Molecular function	• SNARE binding • SNAP receptor activity • protein binding
Cellular component	• terminal bouton • synaptic vesicle membrane • synapse • integral component of membrane • mitochondrion • tertiary granule membrane • azurophil granule membrane • cell junction • integral component of plasma membrane • neuron projection • membrane • cell surface • specific granule membrane • mitochondrial outer membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • cytosol • SNARE complex
Biological process	• SNARE complex assembly • vesicle fusion • vesicle-mediated transport • exocytosis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6843


22317

Ensembl


ENSG00000139190


ENSMUSG00000030337

UniProt


P23763


Q62442

RefSeq (mRNA)


NM_001297438 NM_014231 NM_016830 NM_199245


NM_001080557 NM_009496

RefSeq (protein)


NP_001284367.1 NP_055046.1 NP_058439.1 NP_954740.1


NP_001074026.1 NP_033522.1

Location (UCSC)

Chr 12: 6.46 – 6.47 Mb

Chr 6: 125.22 – 125.25 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Vesicle-associated membrane protein 1 is a protein that in humans is encoded by the VAMP1 gene.^[3]^[4]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.^[4]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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Nicotine Activity on Dopaminergic Neurons edit

↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Archer BT III, Ozcelik T, Jahn R, Francke U, Sudhof TC (Nov 1990). "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2". J Biol Chem. 265 (28): 17267–73. PMID 1976629.
1 2 "Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)".

Ravichandran V, Chawla A, Roche PA (1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues.". J. Biol. Chem. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
Jagadish MN, Fernandez CS, Hewish DR, et al. (1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.". Biochem. J. 317. ( Pt 3): 945–54. doi:10.1042/bj3170945. PMC 1217577. PMID 8760387.
Annaert WG, Becker B, Kistner U, et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31.". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.
Weir ML, Klip A, Trimble WS (1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.". Biochem. J. 333. ( Pt 2): 247–51. doi:10.1042/bj3330247. PMC 1219579. PMID 9657962.
Isenmann S, Khew-Goodall Y, Gamble J, et al. (1999). "A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal.". Mol. Biol. Cell. 9 (7): 1649–60. doi:10.1091/mbc.9.7.1649. PMC 25402. PMID 9658161.
Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
Berglund L, Hoffmann HJ, Dahl R, Petersen TE (1999). "VAMP-1 has a highly variable C-terminus generated by alternative splicing.". Biochem. Biophys. Res. Commun. 264 (3): 777–80. doi:10.1006/bbrc.1999.1588. PMID 10544008.
Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay.". Mol. Cell. Neurosci. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

1kil: Three-dimensional structure of the complexin/SNARE complex

1n7s: High Resolution Structure of a Truncated Neuronal SNARE Complex

Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6

R-SNARE	Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3

Synaptotagmin

SYT1
SYT2
SYT3
SYT4
SYT5
SYT6
SYT7
SYT8
SYT9
SYT10
SYT11
SYT12
SYT13
SYT14
SYT15
SYT16
SYT17

Other

Small GTPase: RAB3A

COPI

Coatomer
- COPA
- COPB1
- COPB2
- COPE
- COPG
- COPG2
- COPZ1
- COPZ2

Archain

Small GTPase: ARF

COPII

Vesicle formation: SEC23A

Small GTPase: SAR1A

RME/Clathrin

CLTA
CLTB
CLTC

Caveolae

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3

Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1

Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2

Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1

LMAN1

LYST

BLOC-1:	DTNBP1 BLOC153

BLOC-2:	HPS3 HPS5 HPS6

BLOC-3:	HPS1 HPS4

Coats:	Retromer TIP47

Small GTPase

Dynamin
- DNM1
- DNM2
- DNM3

Other

Sorting nexins

SYNRG

See also vesicular transport protein disorders

This article is issued from Wikipedia - version of the 6/6/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

VAMP1

Interactive pathway map

References

Further reading