Uridine triphosphate

Uridine triphosphate
Skeletal formula of UTP
Ball-and-stick model of the UTP molecule as an anion
IUPAC name
[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan- 2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
63-39-8 YesY
ECHA InfoCard 100.000.508
MeSH Uridine+triphosphate
PubChem 1181
Molar mass 484.141
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Uridine-5'-triphosphate (UTP) is a pyrimidine Nucleoside triphosphate, consisting of the organic base uracil linked to the 1' carbon of the ribose sugar, and esterified with tri-phosphoric acid at the 5' position. Its main role is as substrate for the synthesis of RNA during transcription.

Role in metabolism

UTP also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of ATP, but more specific. When UTP activates a substrate, UDP-substrate is usually formed and inorganic phosphate is released. UDP-glucose enters the synthesis of glycogen. UTP is used in the metabolism of galactose, where the activated form UDP-galactose is converted to UDP-glucose. UDP-glucuronate is used to conjugate bilirubin to a more water-soluble bilirubin diglucuronide.

Role in receptor mediation

UTP also has roles in mediating responses by extracellular binding to the P2Y receptors of cells. UTP and its derivatives are still being investigated for their applications in human medicine.

See also

This article is issued from Wikipedia - version of the 8/21/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.