UBL5

UBL5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1P0R, 4PYU

Identifiers

UBL5, HUB1, ubiquitin like 5

External IDs

MGI: 1913427 HomoloGene: 83305 GeneCards: UBL5

Gene ontology
Molecular function	• molecular function • protein binding • protein tag
Cellular component	• cytoplasm • nucleus
Biological process	• mRNA splicing, via spliceosome • cellular protein modification process • biological process • positive regulation of protein targeting to mitochondrion
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


59286


66177


ENSG00000198258


ENSMUSG00000084786


Q9BZL1


Q9EPV8

RefSeq (mRNA)


NM_024292 NM_001048241


NM_025401 NM_001310746

RefSeq (protein)


NP_001041706.1 NP_077268.1 NP_001041706.1 NP_077268.1


NP_079677.1

Location (UCSC)

Chr 19: 9.83 – 9.83 Mb

Chr 9: 20.64 – 20.65 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Ubiquitin-like protein 5 is a protein that in humans is encoded by the UBL5 gene.^[3]

It has been shown that in C. elegans mitochondria treated to lower expression of certain electron transport chain proteins during the L3/L4 stage, its expression levels is higher leading to increased lifespans.^[4]

Ubiquitin-like proteins (UBLs) are thought to be reversible modulators of protein function rather than protein degraders like ubiquitin (MIM 191339).[supplied by OMIM]^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: UBL5 ubiquitin-like 5".
↑ Mitochondrial Stress Signals Revise an Old Aging Theory - DOI 10.1016/j.cell.2010.12.023

Further reading

Friedman JS, Koop BF, Raymond V, Walter MA (2001). "Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes". Genomics. 71 (2): 252–5. doi:10.1006/geno.2000.6439. PMID 11161819.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kantham L, Kerr-Bayles L, Godde N, et al. (2003). "Beacon interacts with cdc2/cdc28-like kinases". Biochem. Biophys. Res. Commun. 304 (1): 125–9. doi:10.1016/S0006-291X(03)00549-7. PMID 12705895.
McNally T, Huang Q, Janis RS, et al. (2004). "Structural analysis of UBL5, a novel ubiquitin-like modifier". Protein Sci. 12 (7): 1562–6. doi:10.1110/ps.0382803. PMC 2323916. PMID 12824502.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wilkinson CR, Dittmar GA, Ohi MD, et al. (2005). "Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast". Curr. Biol. 14 (24): 2283–8. doi:10.1016/j.cub.2004.11.058. PMID 15620657.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

1p0r: Solution Structure of UBL5 a human Ubiquitin-Like Protein

1uh6: Solution Structure of the murine ubiquitin-like 5 protein from RIKEN cDNA 0610031K06

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