Tubulointerstitial nephritis and uveitis

Tubulointerstitial nephritis and uveitis
Classification and external resources
ICD-10 Xxx.x
ICD-9-CM xxx
OMIM 607665
MeSH C536922

Tubulointerstitial nephritis and uveitis (TINU) is a rare medical condition in which there is uveitis (inflammation of the uvea in the eye) together with tubulointerstitial nephritis (inflammation of the tubules inside the kidney).


Uveitis may cause pain of the affected eye together with changes in vision. It may be accompanied by nonspecific systemic symptoms such as fever, involuntary weight loss, fatigue, loss of appetite, abdominal pain, and joint pains.[1]


It is a very rare disease. Approximately 200 cases were reported in medical journals in the 35 years after its initial description.[1] Altogether, more than 100 cases have been reported in Japan.[2]


It was first described in 1975.[1][3]


  1. 1 2 3 Mackensen, F; Billing, H (November 2009). "Tubulointerstitial nephritis and uveitis syndrome.". Current opinion in ophthalmology. 20 (6): 525–31. doi:10.1097/ICU.0b013e3283318f9a. PMID 19752730.
  2. Matsumoto, Keiichiro; Fukunari, Kenichi; Ikeda, Yuji; Miyazono, Motoaki; Kishi, Tomoya; Matsumoto, Ryoko; Fukuda, Makoto; Uchiumi, Saori; Yoshizaki, Mai (2015-01-01). "A report of an adult case of tubulointerstitial nephritis and uveitis (TINU) syndrome, with a review of 102 Japanese cases". The American Journal of Case Reports. 16: 119–123. doi:10.12659/AJCR.892788. ISSN 1941-5923. PMC 4347719Freely accessible. PMID 25725230.
  3. Dobrin, RS; Vernier, RL; Fish, AL (September 1975). "Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome.". The American Journal of Medicine. 59 (3): 325–33. doi:10.1016/0002-9343(75)90390-3. PMID 1163543.
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