Taurochenodeoxycholate 6α-hydroxylase
| Taurochenodeoxycholate 6alpha-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.97 | ||||||||
| CAS number | 105669-85-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Taurochenodeoxycholate 6alpha-hydroxylase (EC 1.14.13.97, CYP3A4, CYP4A21, taurochenodeoxycholate 6alpha-monooxygenase) is an enzyme with systematic name taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (1) taurochenodeoxycholate + NADPH + H+ + O2 taurohyocholate + NADP+ + H2O
- (2) lithocholate + NADPH + H+ + O2 hyodeoxycholate + NADP+ + H2O
Taurochenodeoxycholate 6α-hydroxylase is a heme-thiolate protein (P-450).
See also
References
- ↑ Araya, Z.; Wikvall, K. (1999). "6α-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes". Biochim. Biophys. Acta. 1438 (1): 47–54. doi:10.1016/s1388-1981(99)00031-1. PMID 10216279.
- ↑ Araya, Z.; Hellman, U.; Hansson, R. (1995). "Characterisation of taurochenodeoxycholic acid 6α-hydroxylase from pig liver microsomes". Eur. J. Biochem. 231 (3): 855–861. doi:10.1111/j.1432-1033.1995.0855d.x. PMID 7649186.
- ↑ Kramer, W.; Sauber, K.; Baringhaus, K.H.; Kurz, M.; Stengelin, S.; Lange, G.; Corsiero, D.; Girbig, F.; Konig, W.; Weyland, C. (2001). "Identification of the bile acid-binding site of the ileal lipid-binding protein by photoaffinity labeling, matrix-assisted laser desorption ionization-mass spectrometry, and NMR structure". J. Biol. Chem. 276 (10): 7291–7301. doi:10.1074/jbc.M006877200. PMID 11069906.
- ↑ Lundell, K.; Hansson, R.; Wikvall, K. (2001). "Cloning and expression of a pig liver taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily". J. Biol. Chem. 276 (13): 9606–9612. doi:10.1074/jbc.M006584200. PMID 11113117.
- ↑ Lundell, K.; Wikvall, K. (2003). "Gene structure of pig sterol 12α-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21)". Biochim. Biophys. Acta. 1634 (3): 86–96. doi:10.1016/j.bbalip.2003.09.002. PMID 14643796.
- ↑ Russell, D.W. (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–174. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
External links
- Taurochenodeoxycholate 6alpha-hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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