The Talpur Baloch soon gained power and overthrew the Kalhora after the Battle of Halani. Peace between the two warring tribes was soon established after the Mughal Emperor Akbar Shah II issued a Firman in the year 1783, which designated Mir Fateh Ali Khan Talpur as the new Nawab of Sindh. This brought an end to the ferocious fighting and the defeat of the ruling Kalhora by the Talpur tribes.
The Talpur dynasty (Urdu: سلسله تالپور) (Balochi: ٽالپور خاندان) was a dynasty of the Talpur Baloch tribe that conquered and ruled Sindh, and other parts of present-day Pakistan, from 1783 to 1843. The Talpur dynasty was defeated by the British invaders in 1843 at the Battle of Miani.
|Tenure||Amir of Khairpur|
|1811 - 20 December 1842||Rustam Ali Khan|
|1829–1839||Mubarak Ali Khan (challenger)|
|1839–1842||Nasser Khan (challenger)|
|20 December 1842 - 2 April 1894||Ali Murad Khan|
|2 April 1894 – 6 March 1909||Faiz Mohammad Khan I|
|6 March 1909 – 8 February 1921||Imam Bakhsh Khan|
|8 February 1921 – 25 June 1921||Interregnum|
|25 June 1921 – 25 December 1935||Ali Nawaz Khan|
|25 December 1935 – 19 July 1947||Faiz Mohammad Khan II|
|19 July 1947 – 14 October 1955||George Ali Murad Khan|
|14 October 1955||State of Khairpur abolished|