Clinical data
Routes of
oral, topical
ATC code none
CAS Number 201410-53-9 YesY
PubChem (CID) 9799888
ChemSpider 7975653 N
ChEBI CHEBI:101854 N
Chemical and physical data
Formula C21H23N5S
Molar mass 377.505 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Talarozole (formerly R115866, planned trade name Rambazole) is an investigational drug for the treatment of acne, psoriasis and other keratinization disorders.

Talarozole inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase. Because of this mechanism, it is called a retinoic acid metabolism blocking agent (RAMBA).[1]


  1. Giltaire, S; Herphelin F; Frankart A; Hérin M; Stoppie P; Poumay Y (11 December 2008). "The CYP26 inhibitor R115866 potentiates the effects of all-trans retinoic acid on cultured human epidermal keratinocytes". Br J Dermatol. 160 (3): 505–13. doi:10.1111/j.1365-2133.2008.08960.x. PMID 19120344.

This article is issued from Wikipedia - version of the 9/8/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.