TRNA pseudouridine38/39 synthase

TRNA pseudouridine^38/39 synthase (EC 5.4.99.45, Deg1, Pus3p, pseudouridine synthase 3) is an enzyme with systematic name tRNA-uridine^38/39 uracil mutase.^[1]^[2] This enzyme catalyses the following chemical reaction

tRNA uridine^38/39

\rightleftharpoons

tRNA pseudouridine^38/39

The enzyme from Saccharomyces cerevisiae is active only towards uridine³⁸ and uridine³⁹.

References

↑ Lecointe, F.; Simos, G.; Sauer, A.; Hurt, E.C.; Motorin, Y.; Grosjean, H. (1998). "Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of Ψ³⁸ and Ψ³⁹ in tRNA anticodon loop". J. Biol. Chem. 273: 1316–1323. doi:10.1074/jbc.273.3.1316. PMID 9430663.
↑ Chen, J.; Patton, J.R. (2000). "Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA". Biochemistry. 39: 12723–12730. doi:10.1021/bi001109m. PMID 11027153.

Isomerase: mutases (EC 5.4)

5.4.1 Acyl Groups	Lysolecithin acylmutase Precorrin-8X methylmutase

5.4.2 Phosphomutases	Phosphoglycerate mutase Bisphosphoglycerate mutase Phosphoglucomutase Phosphomannomutase PMM1 PMM2

5.4.99 Other groups	Methylmalonyl-CoA mutase Lanosterol synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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