TRIM23

TRIM23
Identifiers
Aliases	TRIM23, ARD1, ARFD1, RNF46, tripartite motif containing 23
External IDs	MGI: 1933161 HomoloGene: 1251 GeneCards: TRIM23
Gene ontology Molecular function • enzyme activator activity • identical protein binding • GTPase activity • ubiquitin-protein transferase activity • protein binding • ligase activity • GDP binding • zinc ion binding • metal ion binding • nucleotide binding • GTP binding Cellular component • endomembrane system • Golgi membrane • nucleus • lysosomal membrane • intracellular • extracellular exosome • membrane • lysosome • cytoplasm • Golgi apparatus Biological process • small GTPase mediated signal transduction • protein ubiquitination • viral process • positive regulation of catalytic activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	373	81003
Ensembl	ENSG00000113595	ENSMUSG00000021712
UniProt	P36406	Q8BGX0
RefSeq (mRNA)	NM_001656 NM_033227 NM_033228	NM_030731
RefSeq (protein)	NP_001647.1 NP_150230.1 NP_150231.1	NP_109656.1
Location (UCSC)	Chr 5: 65.59 – 65.63 Mb	Chr 13: 104.18 – 104.2 Mb
PubMed search	[1]	[2]
Wikidata

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.^[3][4]

Function

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described.^[4]

Interactions

TRIM23 has been shown to interact with TRIM31,^[5] TRIM29^[5] and PSCD1.^[6]

References

Further reading