TIMP1

TIMP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases TIMP1, CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 1
External IDs MGI: 98752 HomoloGene: 36321 GeneCards: TIMP1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

7076

21857

Ensembl

ENSG00000102265

ENSMUSG00000001131

UniProt

P01033
Q6FGX5

P12032

RefSeq (mRNA)

NM_003254

NM_001044384
NM_001294280
NM_011593

RefSeq (protein)

NP_003245.1
NP_003245.1

NP_001037849.1
NP_035723.2

Location (UCSC) Chr X: 47.58 – 47.59 Mb Chr X: 20.87 – 20.87 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms.

This protein is a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.

Other names

Regulation of TIMP expression

Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.[3]

In adrenocortical cells the trophic hormone ACTH induces expression of TIMP-1 and the increase in TIMP expression is also associated with decreased collagenase activity.[4]

Increased expression of TIMP1 has been found to be associated with worse prognosis of various tumors, such as laryngeal carcinoma [5] or melanoma.[6]

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: TIMP1 TIMP metallopeptidase inhibitor 1".
  4. ↑ Reichenstein M, Reich R, LeHoux JG, Hanukoglu I (February 2004). "ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells". Mol. Cell. Endocrinol. 215 (1-2): 109–14. doi:10.1016/j.mce.2003.11.011. PMID 15026182.
  5. ↑ Ma J (Dec 2013). "Upregulated TIMP-1 correlates with poor prognosis of laryngeal squamous cell carcinoma.". Int J Clin Exp Pathol. 15 (1): 246–54. PMC 3885479Freely accessible. PMID 24427345.
  6. ↑ Tarhini AA (Jan 2014). "A four-marker signature of TNF-RII, TGF-α, TIMP-1 and CRP is prognostic of worse survival in high-risk surgically resected melanoma..". J Transl Med. 12. doi:10.1186/1479-5876-12-19. PMC 3909384Freely accessible. PMID 24457057.

Further reading

  • Hornebeck W (2004). "Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival.". Pathol. Biol. 51 (10): 569–73. doi:10.1016/j.patbio.2003.09.003. PMID 14622947. 
  • Gardner J, Ghorpade A (2004). "Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system.". J. Neurosci. Res. 74 (6): 801–6. doi:10.1002/jnr.10835. PMID 14648584. 


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