TFPI2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1ZR0

Identifiers

Aliases

TFPI2, PP5, REF1, TFPI-2, tissue factor pathway inhibitor 2

External IDs

MGI: 108543 HomoloGene: 38194 GeneCards: TFPI2

Gene ontology
Molecular function	• peptidase inhibitor activity • extracellular matrix structural constituent • serine-type endopeptidase inhibitor activity
Cellular component	• proteinaceous extracellular matrix • extracellular region • nucleus • extracellular matrix
Biological process	• hemostasis • negative regulation of peptidase activity • blood coagulation • negative regulation of endopeptidase activity • cellular response to fluid shear stress
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7980


21789

Ensembl


ENSG00000105825


ENSMUSG00000029664

UniProt


P48307


O35536

RefSeq (mRNA)


NM_006528 NM_001271003 NM_001271004


NM_009364

RefSeq (protein)


NP_001257932.1 NP_006519.1


NP_033390.1

Location (UCSC)

Chr 7: 93.89 – 93.89 Mb

Chr 6: 3.96 – 3.99 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Tissue factor pathway inhibitor 2 is a protein that in humans is encoded by the TFPI2 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Miyagi Y, Koshikawa N, Yasumitsu H, Miyagi E, Hirahara F, Aoki I, Misugi K, Umeda M, Miyazaki K (Apr 1995). "cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2". J Biochem. 116 (5): 939–42. PMID 7896752.
↑ Miyagi Y, Yasumitsu H, Mizushima H, Koshikawa N, Matsuda Y, Itoh H, Hori TA, Aoki I, Misugi K, Miyazaki K (Jan 1997). "Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6". DNA Cell Biol. 15 (11): 947–54. doi:10.1089/dna.1996.15.947. PMID 8945635.
↑ "Entrez Gene: TFPI2 tissue factor pathway inhibitor 2".

Bützow R, Huhtala ML, Bohn H, et al. (1988). "Purification and characterization of placental protein 5". Biochem. Biophys. Res. Commun. 150 (1): 483–90. doi:10.1016/0006-291X(88)90546-3. PMID 3276312.
Takayama M, Soma H, Saito T, et al. (1983). "Circulating levels of placental protein 5 in normal and abnormal pregnancies". Gynecol. Obstet. Invest. 16 (1): 13–26. doi:10.1159/000299207. PMID 6884838.
Sprecher CA, Kisiel W, Mathewes S, Foster DC (1994). "Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3353–7. doi:10.1073/pnas.91.8.3353. PMC 43575. PMID 8159751.
Petersen LC, Sprecher CA, Foster DC, et al. (1996). "Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor". Biochemistry. 35 (1): 266–72. doi:10.1021/bi951501d. PMID 8555184.
Miyagi Y, Yasumitsu H, Eki T, et al. (1996). "Assignment of the human PP5/TFPI-2 gene to 7q22 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis". Genomics. 35 (1): 267–8. doi:10.1006/geno.1996.0353. PMID 8661135.
Rao CN, Reddy P, Liu Y, et al. (1996). "Extracellular matrix-associated serine protease inhibitors (Mr 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2". Arch. Biochem. Biophys. 335 (1): 82–92. doi:10.1006/abbi.1996.0484. PMID 8914837.
Iino M, Foster DC, Kisiel W (1998). "Quantification and characterization of human endothelial cell-derived tissue factor pathway inhibitor-2". Arterioscler. Thromb. Vasc. Biol. 18 (1): 40–6. doi:10.1161/01.ATV.18.1.40. PMID 9445254.
Udagawa K, Miyagi Y, Hirahara F, et al. (1998). "Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization". Placenta. 19 (2–3): 217–23. doi:10.1016/S0143-4004(98)90011-X. PMID 9548189.
Shinoda E, Yui Y, Hattori R, et al. (1999). "Tissue factor pathway inhibitor-2 is a novel mitogen for vascular smooth muscle cells". J. Biol. Chem. 274 (9): 5379–84. doi:10.1074/jbc.274.9.5379. PMID 10026147.
Liu Y, Stack SM, Lakka SS, et al. (1999). "Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin". Arch. Biochem. Biophys. 370 (1): 112–8. doi:10.1006/abbi.1999.1371. PMID 10496984.
Kamei S, Kazama Y, Kuijper JL, et al. (2001). "Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene". Biochim. Biophys. Acta. 1517 (3): 430–5. doi:10.1016/S0167-4781(00)00298-0. PMID 11342222.
Crawley JT, Goulding DA, Ferreira V, et al. (2002). "Expression and localization of tissue factor pathway inhibitor-2 in normal and atherosclerotic human vessels". Arterioscler. Thromb. Vasc. Biol. 22 (2): 218–24. doi:10.1161/hq0102.101842. PMID 11834519.
Konduri SD, Osman FA, Rao CN, et al. (2002). "Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas". Oncogene. 21 (6): 921–8. doi:10.1038/sj.onc.1204983. PMID 11840337.
Udagawa K, Yasumitsu H, Esaki M, et al. (2002). "Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts". Placenta. 23 (2–3): 145–53. doi:10.1053/plac.2001.0774. PMID 11945080.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hubé F, Reverdiau P, Iochmann S, et al. (2003). "Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas". Biol. Reprod. 68 (5): 1888–94. doi:10.1095/biolreprod.102.011858. PMID 12606321.
George J, Gondi CS, Dinh DH, Gujrati M, Rao JS (2007). "Restoration of TFPI-2 in a Human Glioblastoma Cell Line Triggers Caspase Mediated Pathway and Apoptosis". Clin Cancer Res. 13 (12): 3507–3517. doi:10.1158/1078-0432.CCR-06-3023. PMC 1905856. PMID 17575213.
Rao CN, Segawa T, Navari JR, et al. (2003). "Methylation of TFPI-2 gene is not the sole cause of its silencing". Int. J. Oncol. 22 (4): 843–8. doi:10.3892/ijo.22.4.843. PMID 12632077.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.

PDB gallery

1zr0: Crystal Structure of Kunitz Domain 1 of Tissue Factor Pathway Inhibitor-2 with Bovine Trypsin

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TFPI2

References

Further reading