Aliases TAAR5, PNR, trace amine associated receptor 5
External IDs MGI: 2685073 HomoloGene: 20850 GeneCards: TAAR5
RNA expression pattern
More reference expression data
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 132.59 – 132.59 Mb Chr 10: 23.97 – 23.97 Mb
PubMed search [1] [2]
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Trace amine-associated receptor 5 is a protein that in humans is encoded by the TAAR5 gene.[3][4][5] In vertebrates, TAAR5 is expressed in the olfactory epithelium.[6]

Human TAAR5 (hTAAR5) is a functional trace amine-associated receptor which acts as an olfactory receptor for tertiary amines.[6][7] Trimethylamine (TMA) and N,N-dimethylethylamine are full agonists of hTAAR5.[7][8][9] The amber-woody fragrance timberol antagonizes this activity of TMA.[10] 3-Iodothyronamine acts as an inverse agonist at hTAAR5.[11]

See also


  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Zeng Z, Fan P, Rand E, Kyaw H, Su K, Madike V, Carter KC, Li Y (Mar 1998). "Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain". Biochem Biophys Res Commun. 242 (3): 575–8. doi:10.1006/bbrc.1997.7591. PMID 9464258.
  4. Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (Feb 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
  5. "Entrez Gene: TAAR5 trace amine associated receptor 5".
  6. 1 2 Liberles SD (2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Curr. Opin. Neurobiol. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMID 25616211. All TAARs except TAAR1 function as olfactory receptors, based on studies in rodent, primate, and fish [4,7,10]. TAAR expression is highly enriched in the olfactory system by quantitative PCR (qPCR) analysis, with little or no expression in other tissues examined [4].
  7. 1 2 Zhang LS, Davies SS (April 2016). "Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions". Genome Med. 8 (1): 46. doi:10.1186/s13073-016-0296-x. PMC 4840492Freely accessible. PMID 27102537.
    Table 2: Microbial metabolites: their synthesis, mechanisms of action, and effects on health and disease
    Figure 1: Molecular mechanisms of action of indole and its metabolites on host physiology and disease
  8. Wallrabenstein I, Kuklan J, Weber L, Zborala S, Werner M, Altmüller J, Becker C, Schmidt A, Hatt H, Hummel T, Gisselmann G (2013). "Human trace amine-associated receptor TAAR5 can be activated by trimethylamine". PLoS ONE. 8 (2): e54950. doi:10.1371/journal.pone.0054950. PMC 3564852Freely accessible. PMID 23393561.
  9. Zhang J, Pacifico R, Cawley D, Feinstein P, Bozza T (February 2013). "Ultrasensitive detection of amines by a trace amine-associated receptor". J. Neurosci. 33 (7): 3228–39. doi:10.1523/JNEUROSCI.4299-12.2013. PMC 3711460Freely accessible. PMID 23407976. We show that [human TAAR5] responds to the tertiary amine N,N-dimethylethylamine and to a lesser extent to trimethylamine, a structurally related agonist for mouse and rat TAAR5 (Liberles and Buck, 2006; Staubert et al., 2010; Ferrero et al., 2012).
  10. Wallrabenstein I, Singer M, Panten J, Hatt H, Gisselmann G (2015). "Timberol® Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans". PLoS ONE. 10 (12): e0144704. doi:10.1371/journal.pone.0144704. PMC 4684214Freely accessible. PMID 26684881.
  11. Dinter J, Mühlhaus J, Wienchol CL, Yi CX, Nürnberg D, Morin S, Grüters A, Köhrle J, Schöneberg T, Tschöp M, Krude H, Kleinau G, Biebermann H (2015). "Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5". PLoS ONE. 10 (2): e0117774. doi:10.1371/journal.pone.0117774. PMC 4382497Freely accessible. PMID 25706283.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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