Systematic review

For the academic journal, see Systematic Reviews.

A systematic review is a type of literature review that collects and critically analyzes multiple research studies or papers. A review of existing studies is often quicker and cheaper than embarking on a new study. Researchers use methods that are selected before one or more research questions are formulated, and then they aim to find and analyze studies that relate to and answer those questions.[1] Systematic reviews of randomized controlled trials are key in the practice of evidence-based medicine.[2]

An understanding of systematic reviews, and how to implement them in practice, is highly recommended for professionals involved in the delivery of health care. Besides health interventions, systematic reviews may examine clinical tests, public health interventions, environmental interventions,[3] social interventions, adverse effects, and economic evaluations.[4][5] Systematic reviews are not limited to medicine and are quite common in all other sciences where data are collected, published in the literature, and an assessment of methodological quality for a precisely defined subject would be helpful.[6]


A systematic review aims to provide a complete, exhaustive summary of current literature relevant to a research question. The first step in conducting a systematic review is to perform a thorough search of the literature for relevant papers. The Methodology section of a systematic review will list all of the databases and citation indexes that were searched such as Web of Science, Embase, and PubMed and any individual journals that were searched. The titles and abstracts of identified articles are checked against pre-determined criteria for eligibility and relevance to form an inclusion set. This set will relate back to the research problem. Each included study may be assigned an objective assessment of methodological quality preferably by using methods conforming to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (the current guideline)[7] or the high quality standards of Cochrane collaboration.[8]

Systematic reviews often, but not always, use statistical techniques (meta-analysis) to combine results of eligible studies, or at least use scoring of the levels of evidence depending on the methodology used. An additional rater may be consulted to resolve any scoring differences between raters.[6] Systematic review is often applied in the biomedical or healthcare context, but it can be applied in any field of research. Groups like the Campbell Collaboration are promoting the use of systematic reviews in policy-making beyond just healthcare.

A systematic review uses an objective and transparent approach for research synthesis, with the aim of minimizing bias. While many systematic reviews are based on an explicit quantitative meta-analysis of available data, there are also qualitative reviews which adhere to standards for gathering, analyzing and reporting evidence.[9] The EPPI-Centre has been influential in developing methods for combining both qualitative and quantitative research in systematic reviews.[10] The PRISMA statement[11] suggests a standardized way to ensure a transparent and complete reporting of systematic reviews, and is now required for this kind of research by more than 170 medical journals worldwide.[12]

Recent developments in systematic reviews include realist reviews,[13] and the meta-narrative approach.[14][15] These approaches try to overcome the problems of methodological and epistemological heterogeneity in the diverse literatures existing on some subjects.


The main stages of a systematic review are:

A visualisation of data being 'extracted' and 'combined' in a Cochrane systematic review.[16]
  1. Defining a question and agreeing an objective method.[16]
  2. A search for relevant data from research that matches certain criteria. For example, only selecting research that is good quality and answers the defined question.[16]
  3. 'Extraction' of relevant data. This can include how the research was done (often called the method or 'intervention'), who participated in the research (including how many people), how it was paid for (for example funding sources) and what happened (the outcomes).[16]
  4. Assess the quality of the data by judging it against criteria identified at the first stage.[16]
  5. Analyse and combine the data (using complex statistical methods) which give an overall result from all of the data. This combination of data can be visualised using a blobbogram (also called a forest plot).[16] The diamond in the blobbogram represents the combined results of all the data included. Because this combined result uses data from more sources than just one data set, it's considered more reliable and better evidence, as the more data there is, the more confident we can be of conclusions.[16]

Once these stages are complete, the review may be published, disseminated and translated into practice after being adopted as evidence.

Cochrane Collaboration

The Cochrane Collaboration is a group of over 31,000 specialists in healthcare who systematically review randomised trials of the effects of prevention, treatments and rehabilitation as well as health systems interventions. When appropriate, they also include the results of other types of research. Cochrane Reviews are published in The Cochrane Database of Systematic Reviews section of the Cochrane Library. The 2015 impact factor for The Cochrane Database of Systematic Reviews was 6.103, and it was ranked 12th in the “Medicine, General & Internal” category.[17] There are six types of Cochrane Review:[18][19][20][21]

  1. Intervention reviews assess the benefits and harms of interventions used in healthcare and health policy.
  2. Diagnostic test accuracy reviews assess how well a diagnostic test performs in diagnosing and detecting a particular disease.
  3. Methodology reviews address issues relevant to how systematic reviews and clinical trials are conducted and reported.
  4. Qualitative reviews synthesize qualitative and quantitative evidence to address questions on aspects other than effectiveness.[9]
  5. Prognosis reviews address the probable course or future outcome(s) of people with a health problem.
  6. Overviews of Systematic Reviews (OoRs) are a new type of study in order to compile multiple evidence from systematic reviews into a single document that is accessible and useful to serve as a friendly front end for the Cochrane Collaboration with regard to healthcare decision-making.

The Cochrane Collaboration provides a handbook for systematic reviewers of interventions which "provides guidance to authors for the preparation of Cochrane Intervention reviews."[8] The Cochrane Handbook outlines eight general steps for preparing a systematic review:[8]

  1. Defining the review question(s) and developing criteria for including studies
  2. Searching for studies
  3. Selecting studies and collecting data
  4. Assessing risk of bias in included studies
  5. Analysing data and undertaking meta-analyses
  6. Addressing reporting biases
  7. Presenting results and "summary of findings" tables
  8. Interpreting results and drawing conclusions

The Cochrane Handbook forms the basis of two sets of standards for the conduct and reporting of Cochrane Intervention Reviews (MECIR - Methodological Expectations of Cochrane Intervention Reviews)[22]

The Cochrane Collaboration logo visually represents how results from some systematic reviews can be explained.[23] The lines within illustrate the summary results from an iconic systematic review showing the benefit of corticosteroids, which 'has probably saved thousands of premature babies'.[24]

The Campbell Collaboration

The Campbell Collaboration is one of a number of groups promoting evidence-based policy in the social sciences. The Campbell Collaboration "helps people make well-informed decisions by preparing, maintaining and disseminating systematic reviews in education, crime and justice, social welfare and international development.[2] It is a sister initiative of Cochrane. The Campbell Collaboration was created in 2000 and the inaugural meeting in Philadelphia, USA, attracted 85 participants from 13 countries.[25]

Strengths and weaknesses of systematic reviews

While systematic reviews are regarded as the strongest form of medical evidence, a review of 300 studies found that not all systematic reviews were equally reliable, and that their reporting can be improved by a universally agreed upon set of standards and guidelines.[26] A further study by the same group found that of 100 systematic reviews monitored, 7% needed updating at the time of publication, another 4% within a year, and another 11% within 2 years; this figure was higher in rapidly changing fields of medicine, especially cardiovascular medicine.[27] A 2003 study suggested that extending searches beyond major databases, perhaps into grey literature, would increase the effectiveness of reviews.[28]

Roberts and colleagues highlighted the problems with systematic reviews, particularly those conducted by the Cochrane Collaboration, noting that published reviews are often biased, out of date and excessively long.[29] They criticized Cochrane reviews as not being sufficiently critical in the selection of trials and including too many of low quality. They proposed several solutions, including limiting studies in meta-analyses and reviews to registered clinical trials, requiring that original data be made available for statistical checking, paying greater attention to sample size estimates, and eliminating dependence on only published data.

Some of these difficulties were noted early on as described by Altman: "much poor research arises because researchers feel compelled for career reasons to carry out research that they are ill equipped to perform, and nobody stops them."[30] Methodological limitations of meta-analysis have also been noted.[31] Another concern is that the methods used to conduct a systematic review are sometimes changed once researchers see the available trials they are going to include.[32] Bloggers have described retractions of systematic reviews and published reports of studies included in published systematic reviews.[33][34][35]

Systematic reviews are increasingly prevalent in other fields, such as international development research.[36] Subsequently, a number of donors – most notably the UK Department for International Development (DFID) and AusAid – are focusing more attention and resources on testing the appropriateness of systematic reviews in assessing the impacts of development and humanitarian interventions.[36]

See also


  1. "systematic review". GET-IT glossary. Retrieved 18 November 2015.
  2. "What is EBM?". Centre for Evidence Based Medicine. 2009-11-20. Archived from the original on 2011-04-06. Retrieved 2011-06-17.
  3. Bilotta, G.S., Milner, A.M. and Boyd, I., 2014. On the use of systematic reviews to inform environmental policies. Environmental Science & Policy, 42, pp.67-77.
  4. Systematic reviews: CRD's guidance for undertaking reviews in health care. York: University of York, Centre for Reviews and Dissemination, 2008. ISBN 978-1-900640-47-3. Retrieved 2011-06-17.
  5. Petticrew M, Roberts H. Systematic reviews in the social sciences. Wiley Blackwell, 2006.
  6. 1 2 Herman J. Ader; Gideon J. Mellenbergh; David J. Hand (2008). "Methodological quality". Advising on Research Methods: A consultant's companion. Johannes van Kessel Publishing. ISBN 978-90-79418-02-2.
  7. "PRISMA". Retrieved 2013-08-29.
  8. 1 2 3 Higgins JPT; Green S (eds.). "Cochrane handbook for systematic reviews of interventions, version 5.1.0 (updated March 2011)". The Cochrane Collaboration. Retrieved 2 June 2016.
  9. 1 2 Bearman, Margaret; Dawson, Phillip. "Qualitative synthesis and systematic review in health professions education". Medical Education. 47 (3): 252–260. doi:10.1111/medu.12092.
  10. Thomas, J.; Harden, A; Oakley, A; Oliver, S; Sutcliffe, K; Rees, R; Brunton, G; Kavanagh, J (2004). "Integrating qualitative research with trials in systematic reviews". BMJ. 328 (7446): 1010–2. doi:10.1136/bmj.328.7446.1010. PMC 404509Freely accessible. PMID 15105329.
  11. Liberati, Alessandro; Altman, Douglas G.; Tetzlaff, Jennifer; Mulrow, Cynthia; Gøtzsche, Peter C.; Ioannidis, John P. A.; Clarke, Mike; Devereaux, P. J.; et al. (2009). "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration". PLoS Medicine. 6 (7): e1000100. doi:10.1371/journal.pmed.1000100. PMC 2707010Freely accessible. PMID 19621070.
  12. "PRISMA Endorsers". Retrieved 1 June 2016.
  13. Pawson, R.; Greenhalgh, T.; Harvey, G.; Walshe, K. (2005). "Realist review - a new method of systematic review designed for complex policy interventions". Journal of Health Services Research & Policy. 10: 21–34. doi:10.1258/1355819054308530.
  14. MacFarlane, Fraser; Kyriakidou, Olivia; Bate, Paul; Peacock, Richard; Greenhalgh, Trisha (2005). Diffusion of Innovations in Health Service Organisations: A Systematic Literature. Studies in Urban and Social Change. Blackwell Publishing Professional. ISBN 0-7279-1869-9.
  15. Greenhalgh, Trisha; Potts, Henry W.W.; Wong, Geoff; Bark, Pippa; Swinglehurst, Deborah (2009). "Tensions and Paradoxes in Electronic Patient Record Research: A Systematic Literature Review Using the Meta-narrative Method". Milbank Quarterly. 87 (4): 729–88. doi:10.1111/j.1468-0009.2009.00578.x. JSTOR 25593645. PMC 2888022Freely accessible. PMID 20021585.
  16. 1 2 3 4 5 6 7 "Animated Storyboard: What Are Systematic Reviews?". Cochrane Consumers and Communication. Retrieved 1 June 2016.
  17. The Cochrane Library. 2015 impact factor. Cochrane Database of Systematic Reviews (CDSR) Retrieved 2016-07-20.
  18. Review Manager (RevMan) [Computer program]. Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
  19. The Cochrane Library
  20. Silva V, Grande AJ, Carvalho AP, Martimbianco AL, Riera R (2014). "Overview of systematic reviews - a new type of study. Part II". Sao Paulo Med J. 133: 206–217. doi:10.1590/1516-3180.2013.8150015.
  21. Silva V, Grande AJ, Martimbianco AL, Riera R, Carvalho AP (2012). "Overview of systematic reviews - a new type of study. part I: why and for whom?". Sao Paulo Med J. 130 (6): 398–404. doi:10.1590/S1516-31802012000600007.
  22. "Methodological Expectations of Cochrane Intervention Reviews (MECIR)". Retrieved 6 October 2014.
  23. anonymous. "Animated Storyboard: What Are Systematic Reviews? | Cochrane Consumers and Communication". Retrieved 2016-06-01.
  24. "Our logo | Cochrane". Retrieved 2016-06-01.
  25. User, Super. "History - Campbell". Retrieved 2016-09-27.
  26. Moher, David; Tetzlaff, Jennifer; Tricco, Andrea C.; Sampson, Margaret; Altman, Douglas G. (2007). "Epidemiology and Reporting Characteristics of Systematic Reviews". PLoS Medicine. 4 (3): e78. doi:10.1371/journal.pmed.0040078. PMC 1831728Freely accessible. PMID 17388659.
  27. Shojania, Kaveh G.; Sampson, Margaret; Ansari, Mohammed T.; Ji, Jun; Doucette, Steve; Moher, David (2007). "How Quickly Do Systematic Reviews Go Out of Date? A Survival Analysis". Annals of Internal Medicine. 147 (4): 224–33. doi:10.7326/0003-4819-147-4-200708210-00179. PMID 17638714.
  28. Savoie, Isabelle; Helmer, Diane; Green, Carolyn J.; Kazanjian, Arminée (2003). "Beyond Medline: reducing bias through extended systematic review search". International Journal of Technology Assessment in Health Care. 19 (1): 168–78. doi:10.1017/S0266462303000163. PMID 12701949.
  29. Roberts, I; Ker, K; Edwards, P; Beecher, D; Manno, D; Sydenham, E (3 June 2015). "The knowledge system underpinning healthcare is not fit for purpose and must change.". BMJ (Clinical research ed.). 350: h2463. doi:10.1136/bmj.h2463. PMID 26041754.
  30. Altman, DG (29 January 1994). "The scandal of poor medical research.". BMJ (Clinical research ed.). 308 (6924): 283–4. doi:10.1136/bmj.308.6924.283. PMID 8124111.
  31. Shapiro, S (1 November 1994). "Meta-analysis/Shmeta-analysis.". American Journal of Epidemiology. 140 (9): 771–8. PMID 7977286.
  32. Page, MJ; McKenzie, JE; Kirkham, J; Dwan, K; Kramer, S; Green, S; Forbes, A (Oct 1, 2014). "Bias due to selective inclusion and reporting of outcomes and analyses in systematic reviews of randomised trials of healthcare interventions.". The Cochrane database of systematic reviews. 10: MR000035. doi:10.1002/14651858.MR000035.pub2. PMID 25271098.
  33. "Retraction Of Scientific Papers For Fraud Or Bias Is Just The Tip Of The Iceberg". IFL Science!. Retrieved 29 June 2015.
  34. "Retraction and republication for Lancet Resp Med tracheostomy paper". Retraction Watch. Retrieved 29 June 2015.
  35. "BioMed Central retracting 43 papers for fake peer review". Retraction Watch.
  36. 1 2 Hagen-Zanker, Jessica; Duvendack, Maren; Mallett, Richard; Slater, Rachel; Carpenter, Samuel; Tromme, Mathieu (January 2012). "Making systematic reviews work for international development research". Overseas Development Institute.
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  1. Nunn, Jack (2015-10-01), English: This video explains why systematic reviews are important and how they are done. This includes an explanation of how the effects of interventions are compared in order to provide evidence., retrieved 2016-06-01
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