Squamous metaplasia

Micrograph showing squamous metaplasia (centre of image) in an atypical polypoid adenomyoma. H&E stain.

Squamous metaplasia refers to benign non-cancerous change (metaplasia) of surfacing lining cells (epithelium) to a squamous morphology.


Common sites for squamous metaplasia include the bladder and cervix. Smokers often exhibit squamous metaplasia in the linings of their airways. These changes don't signify a specific disease, but rather usually represent the body's response to stress or irritation. Vitamin A deficiency or overdose can also lead to squamous metaplasia.[1]

Uterine cervix

In regard to the cervix, squamous metaplasia can sometimes be found in the endocervix, as it is composed of simple columnar epithelium, whereas the ectocervix is composed of stratified squamous non-keratinized epithelium .[2]


Squamous metaplasia may be seen in the context of benign lesions (e.g. atypical polypoid adenomyoma), chronic irritation or cancer (e.g. endometrioid endometrial carcinoma).

See also


  1. Goralczyk, R (2009). "ß-Carotene and Lung Cancer in Smokers: Review of Hypotheses and Status of Research". Nutrition and Cancer. 61 (6): 767–774. doi:10.1080/01635580903285155. PMID 20155614.
  2. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; & Mitchell, Richard N. (2007) Robbins Basic Pathology (8th ed.). Saunders Elsevier. pp. 716-720 ISBN 978-1-4160-2973-1
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