Sphingomyelin deacylase
| Sphingomyelin deacylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.1.109 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Sphingomyelin deacylase (EC 3.5.1.109, SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase) is an enzyme with systematic name N-acyl-sphingosylphosphorylcholine amidohydrolase.[1][2][3] This enzyme catalyses the following chemical reaction
- (1) an N-acyl-sphingosylphosphorylcholine + H2O a fatty acid + sphingosylphosphorylcholine;;
- (2) a D-glucosyl-N-acylsphingosine + H2O a fatty acid + D-glucosyl-sphingosine
The enzyme is involved in the sphingolipid metabolism in the epidermis.
References
- ↑ Hara, J.; Higuchi, K.; Okamoto, R.; Kawashima, M.; Imokawa, G. (2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis". J. Invest. Dermatol. 115: 406–413. doi:10.1046/j.1523-1747.2000.00072.x. PMID 10951276.
- ↑ Higuchi, K.; Hara, J.; Okamoto, R.; Kawashima, M.; Imokawa, G. (2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide". Biochem. J. 350: 747–756. doi:10.1042/0264-6021:3500747. PMID 10970788.
- ↑ Ishibashi, M.; Arikawa, J.; Okamoto, R.; Kawashima, M.; Takagi, Y.; Ohguchi, K.; Imokawa, G. (2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis". Lab. Invest. 83: 397–408. doi:10.1097/01.lab.0000059931.66821.92. PMID 12649340.
External links
- Sphingomyelin deacylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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