Sphinganine C4-monooxygenase
| Sphinganine C4-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.169 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Sphinganine C4-monooxygenase (EC 1.14.13.169, sphingolipid C4-hydroxylase, SUR2 (gene), SBH1 (gene), SBH2 (gene)) is an enzyme with systematic name sphinganine,NADPH:oxygen oxidoreductase (C4-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction
- sphinganine + NADPH + H+ + O2 phytosphingosine + NADP+ + H2O
Sphinganine C4-monooxygenase is involved in the biosynthesis of sphingolipids in yeast and plants.
References
- ↑ Haak, D.; Gable, K.; Beeler, T.; Dunn, T. (1997). "Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p". J. Biol. Chem. 272: 29704–29710. doi:10.1074/jbc.272.47.29704. PMID 9368039.
- ↑ Grilley, M.M.; Stock, S.D.; Dickson, R.C.; Lester, R.L.; Takemoto, J.Y. (1998). "Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae". J. Biol. Chem. 273: 11062–11068. doi:10.1074/jbc.273.18.11062. PMID 9556590.
- ↑ Sperling, P.; Ternes, P.; Moll, H.; Franke, S.; Zahringer, U.; Heinz, E. (2001). "Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana". FEBS Lett. 494: 90–94. doi:10.1016/s0014-5793(01)02332-8. PMID 11297741.
External links
- Sphinganine C4-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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