Sodium channel opener
A sodium channel opener is a type of drug which facilitates ion transmission through sodium channels.
Examples include toxins, such as atracotoxins (e.g., robustoxin, versutoxin) and ciguatoxins, which activate voltage-gated sodium channels (VGSCs), and solnatide (AP301), which activates the epithelial sodium channel (ENaC).
- ↑ Shabbir W, Tzotzos S, Bedak M, Aufy M, Willam A, Kraihammer M, Holzner A, Czikora I, Scherbaum-Hazemi P, Fischer H, Pietschmann H, Fischer B, Lucas R, Lemmens-Gruber R (2015). "Glycosylation-dependent activation of epithelial sodium channel by solnatide". Biochem. Pharmacol. 98: 740–53. doi:10.1016/j.bcp.2015.08.003. PMID 26254591.