Slow-reacting substance of anaphylaxis

The slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.[1] It can be found in basophils.

It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.[2] Compared to histamine, it is approximately 5000 times more potent and has a slower onset but longer duration of action.


  1. "Dorland's Medical Dictionary". Retrieved December 15, 2006.
  2. Howard R. Morris; Graham W. Taylor; Priscilla J. Piper; John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". Retrieved December 15, 2006.

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