Clinical data
Routes of
Oral, intramuscular injection, subcutaneous injection
Synonyms Testosterone 17β-trimethylsilyl ether; Testosterone O-trimethylsilyl ether; 17β-Trimethylsilyltestosterone; O-Trimethylsilyltestosterone; 17β-(trimethylsiloxy)androst-4-en-3-one; SC-16148; NSC-95147
CAS Number 5055-42-5
PubChem (CID) 68627
ChemSpider 61886 YesY
KEGG D05837
ChEBI CHEBI:607921
Chemical and physical data
Formula C22H36O2Si
Molar mass 360.613 g/mol
3D model (Jmol) Interactive image

Silandrone (INN, USAN) (developmental code names SC-16148, NSC-95147), also known as testosterone 17β-trimethylsilyl ether or 17β-trimethylsilyltestosterone, as well as 17β-(trimethylsiloxy)androst-4-en-3-one, is a synthetic anabolic-androgenic steroid (AAS) and an androgen ether – specifically, the 17β-trimethylsilyl ether of testosterone – which was developed by the G. D. Searle & Company in the 1960s but was never marketed.[1] It has a very long duration of action when given via subcutaneous or intramuscular injection as well as, notably, significantly greater potency than that of testosterone propionate.[2][3] In addition, it is notable that silandrone, unlike testosterone and most esters of testosterone like testosterone propionate, is orally active.[4]

See also


  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 642–. ISBN 978-1-4757-2085-3.
  2. Saunders FJ (November 1966). "A singularly long-acting ether of testosterone". Proc. Soc. Exp. Biol. Med. 123 (2): 303–4. doi:10.3181/00379727-123-31472. PMID 5951069.
  3. Le Boeuf BJ, Allen JL (1970). "Prolonged reinstatement of sexual behavior in castrated male rats with an ether of testosterone, SC-16148". Hormones and Behavior. 1 (2). doi:10.1016/0018-506X(70)90004-8.
  4. Leland J. Chinn (1969). The Chemistry and Biochemistry of Steroids. Geron-X. p. 97.

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