Clinical data
Routes of
By mouth
ATC code None
CAS Number 860642-69-9
PubChem (CID) 23653789
ChemSpider 24686685
UNII 277V92K32B YesY
KEGG D09378
Chemical and physical data
Formula C29H28F7NO2
Molar mass 555.527 g/mol
3D model (Jmol) Interactive image

Serlopitant (INN,[1] codenamed VPD-737) is a drug which acts as an NK1 receptor antagonist. It was assessed in clinical trials for the treatment of urinary incontinence and overactive bladder, but while it was superior to placebo it provided no advantage over existing approved drugs, and was not approved for further development.[2][3]

See also


  1. "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 62" (PDF). World Health Organization. 2009. pp. 261–2. Retrieved 17 November 2016.
  2. Frenkl, TL; Zhu, H; Reiss, T; Seltzer, O; Rosenberg, E; Green, S (August 2010). "A Multicenter, Double-Blind, Randomized, Placebo Controlled Trial of a Neurokinin-1 Receptor Antagonist for Overactive Bladder". The Journal of Urology. 184 (2): 616–22. doi:10.1016/j.juro.2010.03.147. PMID 20639026.
  3. Payton, S (August 2010). "Urinary Incontinence: Neurokinin Receptor Antagonist Inferior to Tolterodine for OAB". Nature Reviews Urology. 7 (8): 418. doi:10.1038/nrurol.2010.105. PMID 20726068.
This article is issued from Wikipedia - version of the 11/17/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.