Secondary sclerosing cholangitis

Secondary sclerosing cholangitis abbreviated as (SSC) is a disease that is morphologically similar to primary sclerosing cholangitis (PSC) but that originates from a known pathological process. Its clinical and cholangiographic features may mimic PSC, yet its natural history may be more favorable if recognition is prompt and appropriate therapy is introduced. Thus, the diagnosis of PSC requires the exclusion of secondary causes of sclerosing cholangitis and recognition of associated conditions that may potentially imitate its classic cholangiographic features. Secondary causes of SSC include intraductal stone disease, surgical or blunt abdominal trauma, intra-arterial chemotherapy, and recurrent pancreatitis.[1] It has been clearly demonstrated sclerosing cholangitis can develop after an episode of severe bacterial cholangitis.[2] Also it was suggested that it can result from insult to the biliary tree by obstructive cholangitis secondary to choledocholithiasis, surgical damage, trauma, vascular insults, parasites, or congenital fibrocystic disorders. Additional causes of secondary SC are toxic, due to chemical agents or drugs.[3]


  1. Abdalian R, Heathcote EJ (November 2006). "Sclerosing cholangitis: a focus on secondary causes". Hepatology. 44 (5): 1063–74. doi:10.1002/hep.21405. PMID 17058222.
  2. ter Borg PC, van Buuren HR, Depla AC (June 2002). "Bacterial cholangitis causing secondary sclerosing cholangitis: a case report". BMC Gastroenterology. 2: 14. doi:10.1186/1471-230X-2-14. PMC 116430Freely accessible. PMID 12057011.
  3. Kariv R, Konikoff FM (December 2002). "Sclerosing cholangitis--primary, secondary and more..". The Israel Medical Association Journal : IMAJ. 4 (12): 1141–2. PMID 12516911.
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