SYBL1

VAMP7

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DMW

Identifiers

Aliases

VAMP7, SYBL1, TI-VAMP, TIVAMP, VAMP-7, vesicle associated membrane protein 7

External IDs

MGI: 1096399 HomoloGene: 4121 GeneCards: VAMP7

Gene ontology
Molecular function	• SNARE binding • SNAP receptor activity • syntaxin binding • protein binding
Cellular component	• extracellular exosome • transport vesicle • pseudopodium • cytoplasm • transport vesicle membrane • synapse • integral component of membrane • trans-Golgi network • azurophil granule membrane • Golgi apparatus • cell junction • platelet alpha granule • intracellular membrane-bounded organelle • lamellipodium • apical part of cell • neuron projection • membrane • cell surface • phagocytic vesicle membrane • endoplasmic reticulum • perinuclear region of cytoplasm • endoplasmic reticulum membrane • secretory granule • secretory granule membrane • lysosome • cytoplasmic vesicle • late endosome membrane • endosome • phagocytic vesicle • plasma membrane • lysosomal membrane • SNARE complex
Biological process	• autophagosome maturation • vesicle transport along microtubule • vesicle fusion with Golgi apparatus • Golgi to plasma membrane protein transport • positive regulation of histamine secretion by mast cell • SNARE complex assembly • calcium ion regulated exocytosis • triglyceride transport • ER to Golgi vesicle-mediated transport • post-Golgi vesicle-mediated transport • regulation of protein targeting to vacuolar membrane • exocytosis • natural killer cell degranulation • transport • phagocytosis, engulfment • protein transport • endosome to lysosome transport • positive regulation of dendrite morphogenesis • vesicle fusion • vesicle-mediated transport • neutrophil degranulation • eosinophil degranulation • endocytosis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6845


20955

Ensembl


ENSG00000124333


ENSMUSG00000051412

UniProt


P51809


P70280

RefSeq (mRNA)


NM_001145149 NM_001185183 NM_005638


NM_001302138 NM_011515

RefSeq (protein)


NP_001138621.1 NP_001172112.1 NP_005629.1


NP_001289067.1 NP_035645.1

Location (UCSC)

Chr X: 155.88 – 155.94 Mb

n/a

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Vesicle-associated membrane protein 7 (VAMP-7) is a protein that in humans is encoded by the VAMP7 gene.^[3]^[4]^[5]

Function

VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.^[5]

Interactions

SYBL1 has been shown to interact with SNAP23^[6]^[7] and AP3D1.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ D'Esposito M, Ciccodicola A, Gianfrancesco F, Esposito T, Flagiello L, Mazzarella R, Schlessinger D, D'Urso M (Jul 1996). "A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation". Nat. Genet. 13 (2): 227–9. doi:10.1038/ng0696-227. PMID 8640232.
↑ Filippini F, Rossi V, Galli T, Budillon A, D'Urso M, D'Esposito M (Jul 2001). "Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain". Trends Biochem. Sci. 26 (7): 407–9. doi:10.1016/S0968-0004(01)01861-8. PMID 11440841.
1 2 "Entrez Gene: SYBL1 synaptobrevin-like 1".
1 2 Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (Jul 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
↑ Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D (Jun 1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell. 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D (1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell. 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185.
Advani RJ, Yang B, Prekeris R, Lee KC, Klumperman J, Scheller RH (1999). "VAMP-7 mediates vesicular transport from endosomes to lysosomes". J. Cell Biol. 146 (4): 765–76. doi:10.1083/jcb.146.4.765. PMC 2156136. PMID 10459012.
Matarazzo MR, Cuccurese M, Strazzullo M, Vacca M, Curci A, Miano MG, Cocchia M, Mercadante G, Torino A, D'Urso M, Ciccodicola A, D'Esposito M (1999). "Human and mouse SYBL1 gene structure and expression". Gene. 240 (1): 233–8. doi:10.1016/S0378-1119(99)00375-3. PMID 10564831.
Ciccodicola A, D'Esposito M, Esposito T, Gianfrancesco F, Migliaccio C, Miano MG, Matarazzo MR, Vacca M, Franzè A, Cuccurese M, Cocchia M, Curci A, Terracciano A, Torino A, Cocchia S, Mercadante G, Pannone E, Archidiacono N, Rocchi M, Schlessinger D, D'Urso M (2000). "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. doi:10.1093/hmg/9.3.395. PMID 10655549.
Ward DM, Pevsner J, Scullion MA, Vaughn M, Kaplan J (2000). "Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages". Mol. Biol. Cell. 11 (7): 2327–33. doi:10.1091/mbc.11.7.2327. PMC 14922. PMID 10888671.
Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.
Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR (2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nat. Struct. Biol. 9 (2): 107–11. doi:10.1038/nsb746. PMID 11786915.
Müller DJ, Schulze TG, Jahnes E, Cichon S, Krauss H, Kesper K, Held T, Maier W, Propping P, Nöthen MM, Rietschel M (2002). "Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder". Am. J. Med. Genet. 114 (1): 74–8. doi:10.1002/ajmg.10115. PMID 11840509.
Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F (2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". Biochem. J. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC 1222979. PMID 12175335.
Matarazzo MR, De Bonis ML, Gregory RI, Vacca M, Hansen RS, Mercadante G, D'Urso M, Feil R, D'Esposito M (2002). "Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes". Hum. Mol. Genet. 11 (25): 3191–8. doi:10.1093/hmg/11.25.3191. PMID 12444103.
Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
Di Leva F, Ferrante MI, Demarchi F, Caravelli A, Matarazzo MR, Giacca M, D'Urso M, D'Esposito M, Franzé A (2004). "Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements". J. Biol. Chem. 279 (9): 7734–9. doi:10.1074/jbc.M308140200. PMID 14672948.
Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW (2004). "Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis". J. Biol. Chem. 279 (19): 20471–9. doi:10.1074/jbc.M400798200. PMID 14993220.

PDB gallery

2dmw: Solution structure of the LONGIN domain of Synaptobrevin-like protein 1

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SYBL1

Function

Interactions

References

Further reading