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G protein-coupled receptor 27
Symbol GPR27
Alt. symbols SREB1
Entrez 2850
HUGO 4482
OMIM 605187
RefSeq NM_018971
UniProt Q9NS67
Other data
Locus Chr. 3 p21-p14
G protein-coupled receptor 85
Symbol GPR85
Alt. symbols SREB2
Entrez 54329
HUGO 4536
OMIM 605188
RefSeq NM_018970
UniProt P60893
Other data
Locus Chr. 7 q31
G protein-coupled receptor 173
Symbol GPR173
Alt. symbols SREB3
Entrez 54328
HUGO 18186
OMIM 300253
RefSeq NM_018969
UniProt Q9NS66
Other data
Locus Chr. X p11

The SREB (Super Conserved Receptor Expressed in Brain) are a group of related G-protein coupled receptors.[1] Since no endogenous ligands have yet been identified for these receptors, they are classified as orphan receptors.


  1. Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K (2000). "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system". Biochem. Biophys. Res. Commun. 272 (2): 576–82. doi:10.1006/bbrc.2000.2829. PMID 10833454.

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