SPINK2

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2JXD

Identifiers

Aliases

SPINK2, HUSI-II, serine peptidase inhibitor, Kazal type 2

External IDs

HomoloGene: 77717 GeneCards: SPINK2

Gene ontology
Molecular function	• peptidase inhibitor activity • endopeptidase inhibitor activity • protein binding • serine-type endopeptidase inhibitor activity
Cellular component	• extracellular fluid • extracellular region • acrosomal vesicle
Biological process	• regulation of acrosome reaction • negative regulation of peptidase activity • negative regulation of serine-type endopeptidase activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6691


n/a

Ensembl


ENSG00000128040


n/a

UniProt


P20155


n/a

RefSeq (mRNA)

NM_001271718 NM_001271719 NM_001271720 NM_001271721 NM_001271722
NM_021114


n/a

RefSeq (protein)


NP_001258650.1 NP_001258651.1 NP_066937.1


n/a

Location (UCSC)

Chr 4: 56.81 – 56.82 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Serine protease inhibitor Kazal-type 2 also known as acrosin-trypsin inhibitor is a protein that in humans is encoded by the SPINK2 gene.^[2]^[3]

References

↑ "Human PubMed Reference:".
↑ Moritz A, Grzeschik KH, Wingender E, Fink E (Mar 1993). "Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II)". Gene. 123 (2): 277–81. doi:10.1016/0378-1119(93)90138-S. PMID 8428671.
↑ "Entrez Gene: SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)".

^[1]

Wapenaar MC, Monsuur AJ, Poell J, et al. (2007). "The SPINK gene family and celiac disease susceptibility.". Immunogenetics. 59 (5): 349–57. doi:10.1007/s00251-007-0199-5. PMC 1914236. PMID 17333166.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rockett JC, Patrizio P, Schmid JE, et al. (2004). "Gene expression patterns associated with infertility in humans and rodent models.". Mutat. Res. 549 (1-2): 225–40. doi:10.1016/j.mrfmmm.2003.11.017. PMID 15120973.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fink E, Hehlein-Fink C, Eulitz M (1990). "Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones.". FEBS Lett. 270 (1-2): 222–4. doi:10.1016/0014-5793(90)81273-Q. PMID 2226783.
Collins J, Taube W, Fink E, et al. (1992). "Variants of human seminal acrosin inhibitor (HUSI-II) which inhibit human leukocyte elastase.". Biomed. Biochim. Acta. 50 (4-6): 683–5. PMID 1801743.
Möritz A, Lilja H, Fink E (1991). "Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II).". FEBS Lett. 278 (1): 127–30. doi:10.1016/0014-5793(91)80099-O. PMID 1704312.
Dietl T, Kruck J, Schill WB, Fritz H (1977). "Localization of seminal plasma proteinase inhibitors in human spermatozoa as revealed by the indirect immunofluorescence technique.". Hoppe-Seyler's Z. Physiol. Chem. 357 (10): 1333–7. doi:10.1515/bchm2.1976.357.2.1333. PMID 791787.

↑ Lee B, Park I, Jin S, Choi H, Kwon JT, Kim J, Jeong J, Cho BN, Eddy EM, Cho C (2011). "Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes". J. Biol. Chem. 286: 29108–17. doi:10.1074/jbc.M111.244905. PMC 3190718. PMID 21705336.

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SPINK2

See also

References

Further reading