SEMA3F

SEMA3F
Identifiers
Aliases	SEMA3F, SEMA-IV, SEMA4, SEMAK, semaphorin 3F
External IDs	MGI: 1096347 HomoloGene: 20885 GeneCards: SEMA3F
Gene ontology Molecular function • semaphorin receptor binding • neuropilin binding • chemorepellent activity Cellular component • extracellular fluid • extracellular region Biological process • sympathetic ganglion development • ventral trunk neural crest cell migration • semaphorin-plexin signaling pathway involved in neuron projection guidance • negative chemotaxis • positive regulation of cell migration • negative regulation of axon extension involved in axon guidance • semaphorin-plexin signaling pathway involved in axon guidance • axon guidance • sympathetic neuron projection guidance • neural crest cell migration involved in autonomic nervous system development • branchiomotor neuron axon guidance • neural crest cell migration • facial nerve structural organization • nerve development • sympathetic neuron projection extension • trigeminal nerve structural organization • axon extension involved in axon guidance • semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6405	20350
Ensembl	ENSG00000001617	ENSMUSG00000034684
UniProt	Q13275	O88632
RefSeq (mRNA)	NM_004186 NM_001318798 NM_001318800	NM_011349 NM_001311151
RefSeq (protein)	NP_004177.3 NP_001305729.1	NP_001298080.1 NP_035479.2
Location (UCSC)	Chr 3: 50.16 – 50.19 Mb	Chr 9: 107.68 – 107.71 Mb
PubMed search	[1]	[2]
Wikidata

Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.^[3][4][5]

The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993). Sequence comparisons have grouped the secreted semaphorins into 3 general classes (classes 2, 3 and V), all of which also have an immunoglobulin domain. The semaphorin 3 family, consisting of human semaphorins 3A-G (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins 3A-G, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM]^[5]

References

Further reading