Clinical data
Routes of
Synonyms 17α-Propylmesterolone; 17β-Hydroxy-1α-methyl-17α-propyl-5α-androstan-3-one
CAS Number 79243-67-7
PubChem (CID) 71232
ChemSpider 64367
Chemical and physical data
Formula C23H38O2
Molar mass 346.54662 g/mol
3D model (Jmol) Interactive image
Not to be confused with rotenolone.

Rosterolone (INN) (developmental code name SH-434), also known as 17α-propylmesterolone or 17β-hydroxy-1α-methyl-17α-propyl-5α-androstan-3-one, is a steroidal antiandrogen that was first reported in 1984 and was developed for topical administration but was never marketed.[1][2][1] It has shown some efficacy in the treatment of acne, and in animal models lacks systemic effects with topical application.[1][2] Rosterolone is a derivative of mesterolone, which, in contrast, is an androgen and anabolic steroid.[3]

See also


  1. 1 2 3 Luderschmidt, Christoph; Eiermann, Wolfgang; Jawny, Johannes; Bidlingmaier, Frank; Ring, Johannes (1984). "17?-Propylmesterolone (SH 434): an antiandrogenic sebosuppressive substance not influencing circulating testosterone concentrations". Naunyn-Schmiedeberg's Archives of Pharmacology. 328 (2): 214–218. doi:10.1007/BF00512076. ISSN 0028-1298.
  2. 1 2 Singh, Shankar; Gauthier, Sylvain; Labrie, Fernand (2000). "Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships". Current Medicinal Chemistry. 7 (2): 211–247. doi:10.2174/0929867003375371. ISSN 0929-8673.
  3. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 775–. ISBN 978-1-4757-2085-3.

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