CAS Number 143782-63-2
PubChem (CID) 9840708
ChemSpider 8016425
Chemical and physical data
Formula C15H11F3N4O2
Molar mass 336.268 g/mol
3D model (Jmol) Interactive image

RU-58642 is a non-steroidal antiandrogen with very high affinity and selectivity for the androgen receptor (AR), which made it among the most potent and efficacious antiandrogens known at the time of its discovery.[1] It was investigated for topical application for the treatment of androgenetic alopecia (male-pattern baldness), but development did not proceed past initial trial stages, and it is now only used for scientific research into the AR.[2][3]

See also


  1. Battmann, T.; Branche, C.; Bouchoux, F.; Cerede, E.; Philibert, D.; Goubet, F.; Teutsch, G.; Gaillard-Kelly, M. (1998). "Pharmacological profile of RU 58642, a potent systemic antiandrogen for the treatment of androgen-dependent disorders". The Journal of Steroid Biochemistry and Molecular Biology. 64 (1-2): 103–111. doi:10.1016/S0960-0760(97)00151-9. ISSN 0960-0760.
  2. Sims, Natalie A.; Clément-Lacroix, Philippe; Minet, Dominique; Fraslon-Vanhulle, Caroline; Gaillard-Kelly, Martine; Resche-Rigon, Michèle; Baron, Roland (2003). "A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor–deficient mice". Journal of Clinical Investigation. 111 (9): 1319–1327. doi:10.1172/JCI200317246. ISSN 0021-9738.
  3. Windahl, Sara H.; Galien, René; Chiusaroli, Riccardo; Clément-Lacroix, Philippe; Morvan, Frederic; Lepescheux, Liên; Nique, François; Horne, William C.; Resche-Rigon, Michèle; Baron, Roland (2006). "Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor". Journal of Clinical Investigation. 116 (9): 2500–2509. doi:10.1172/JCI28809. ISSN 0021-9738.

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