RIC3

RIC3
Identifiers
Aliases RIC3, AYST720, PRO1385, RIC3 acetylcholine receptor chaperone
External IDs MGI: 2443887 HomoloGene: 49772 GeneCards: RIC3
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

79608

320360

Ensembl

ENSG00000166405

ENSMUSG00000048330

UniProt

Q7Z5B4

Q8BPM6

RefSeq (mRNA)

NM_001135109
NM_001206671
NM_001206672
NM_024557

NM_001038624
NM_178780
NM_001311161

RefSeq (protein)

NP_001128581.1
NP_001193600.1
NP_001193601.1
NP_078833.3

NP_001033713.1
NP_001298090.1
NP_848895.2

Location (UCSC) Chr 11: 8.11 – 8.17 Mb Chr 7: 109.03 – 109.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans.[3] RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT3 receptor and nicotinic acetylcholine receptors,[4][5] particularly the homomeric α7 nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Nguyen M, Alfonso A, Johnson CD, Rand JB (Jun 1995). "Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase". Genetics. 140 (2): 527–35. PMID 7498734.
  4. Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M (Sep 2003). "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression". J Biol Chem. 278 (36): 34411–7. doi:10.1074/jbc.M300170200. PMID 12821669.
  5. "Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)".
  6. Williams ME, Burton B, Urrutia A, et al. (2005). "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells". J. Biol. Chem. 280 (2): 1257–63. doi:10.1074/jbc.M410039200. PMID 15504725.

Further reading


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