RFC5

RFC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LFS
Identifiers
Aliases	RFC5, RFC36, replication factor C subunit 5
External IDs	MGI: 1919401 HomoloGene: 6730 GeneCards: RFC5
Genetically Related Diseases
obesity[1]
Gene ontology Molecular function • nucleotide binding • DNA binding • single-stranded DNA-dependent ATPase activity • protein binding • ATP binding • enzyme binding • DNA clamp loader activity Cellular component • DNA replication factor C complex • Ctf18 RFC-like complex • nucleoplasm • nucleus Biological process • nucleotide-excision repair, DNA gap filling • error-free translesion synthesis • error-prone translesion synthesis • telomere maintenance via recombination • positive regulation of DNA-directed DNA polymerase activity • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • DNA damage response, detection of DNA damage • nucleotide-excision repair, DNA incision, 5'-to lesion • DNA repair • DNA replication • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5985	72151
Ensembl	ENSG00000111445	ENSMUSG00000029363
UniProt	P40937	Q9D0F6
RefSeq (mRNA)	NM_001130112 NM_001130113 NM_001206801 NM_007370 NM_181578	NM_028128
RefSeq (protein)	NP_001123584.1 NP_031396.1 NP_853556.2	NP_082404.1
Location (UCSC)	Chr 12: 118.01 – 118.03 Mb	Chr 5: 117.38 – 117.39 Mb
PubMed search	[2]	[3]
Wikidata

Replication factor C subunit 5 is a protein that in humans is encoded by the RFC5 gene.^[4][5]

Function

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[5]

Interactions

RFC5 has been shown to interact with:

• BRD4,^[6]
• CHTF18,^[7]
• PCNA,^[8][9][10]
• RFC2,^[8][11] and
• RFC4.^{[8][11][12][13]}

References

Further reading