RAB17

RAB17

Identifiers

External IDs

MGI: 104640 HomoloGene: 7502 GeneCards: RAB17

Genetically Related Diseases

Gene ontology
Molecular function	• nucleotide binding • GDP binding • GTP binding • protein binding • GTPase activity
Cellular component	• recycling endosome • endosome • cell projection • membrane • melanosome • plasma membrane • endocytic vesicle • intracellular • neuronal cell body • recycling endosome membrane • dendrite • basolateral plasma membrane • early endosome • apical plasma membrane • extracellular exosome
Biological process	• regulation of endocytosis • regulation of filopodium assembly • small GTPase mediated signal transduction • regulation of synapse assembly • filopodium assembly • regulation of dendrite development • transcytosis • establishment of melanosome localization • melanosome transport • endocytic recycling • transport • protein transport • cilium assembly • immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


64284


19329


ENSG00000124839


ENSMUSG00000026304


Q9H0T7


P35292

RefSeq (mRNA)


NM_022449


NM_001159725 NM_008998

RefSeq (protein)


NP_071894.1 NP_071894.1


NP_001153197.2 NP_033024.1

Location (UCSC)

Chr 2: 237.57 – 237.6 Mb

Chr 1: 90.96 – 90.97 Mb

PubMed search

^[2]

^[3]

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-17 is a protein that in humans is encoded by the RAB17 gene.^[4]^[5]

In melanocytic cells RAB17 gene expression may be regulated by MITF.^[6]

References

↑ "Diseases that are genetically associated with RAB17 view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hunziker W, Peters PJ (Jul 1998). "Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells". J Biol Chem. 273 (25): 15734–41. doi:10.1074/jbc.273.25.15734. PMID 9624171.
↑ "Entrez Gene: RAB17 RAB17, member RAS oncogene family".
↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Lütcke A, Jansson S, Parton RG, et al. (1993). "Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization.". J. Cell Biol. 121 (3): 553–64. doi:10.1083/jcb.121.3.553. PMC 2119572. PMID 8486736.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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