Protein SET

SET
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases SET, 2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA, SET nuclear proto-oncogene
External IDs MGI: 1860267 HomoloGene: 55707 GeneCards: SET
Orthologs
Species Human Mouse
Entrez

6418

56086

Ensembl

ENSG00000119335

ENSMUSG00000054766

UniProt

Q01105

Q9EQU5

RefSeq (mRNA)

NM_001122821
NM_001248000
NM_001248001
NM_003011

NM_001204875
NM_023871

RefSeq (protein)

NP_001116293.1
NP_001234929.1
NP_001234930.1
NP_003002.2

NP_001191804.1
NP_076360.1

Location (UCSC) Chr 9: 128.68 – 128.7 Mb Chr 2: 30.06 – 30.07 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Protein SET is a protein that in humans is encoded by the SET gene.[3][4][5]

Interactions

Protein SET has been shown to interact with:

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Molecular and Cellular Biology. 12 (8): 3346–55. doi:10.1128/mcb.12.8.3346. PMC 364582Freely accessible. PMID 1630450.
  4. Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". The Journal of Biological Chemistry. 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647.
  5. "Entrez Gene: SET SET translocation (myeloid leukemia-associated)".
  6. 1 2 Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/s0092-8674(01)00196-9. PMID 11163245.
  7. Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/mcb.22.8.2810-2820.2002. PMC 133744Freely accessible. PMID 11909973.
  8. Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.
  9. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/mcb.23.23.8528-8541.2003. PMC 262669Freely accessible. PMID 14612398.
  10. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell. 112 (5): 659–72. doi:10.1016/s0092-8674(03)00150-8. PMID 12628186.

Further reading

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