Proglucagon is a protein that is cleaved from preproglucagon. Preproglucagon in humans is encoded by the GCG gene.[1][2]

Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon. It is cleaved into the following components:


  1. Schroeder WT, Lopez LC, Harper ME, Saunders GF (1984). "Localization of the human glucagon gene (GCG) to chromosome segment 2q36–37". Cytogenet. Cell Genet. 38 (1): 76–9. doi:10.1159/000132034. PMID 6546710.
  2. White JW, Saunders GF (June 1986). "Structure of the human glucagon gene". Nucleic Acids Res. 14 (12): 4719–30. doi:10.1093/nar/14.12.4719. PMC 311486Freely accessible. PMID 3725587.

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