Positive end-expiratory pressure

Positive end-expiratory pressure (PEEP) is the pressure in the lungs (alveolar pressure) above atmospheric pressure (the pressure outside of the body) that exists at the end of expiration.[1] The two types of PEEP are extrinsic PEEP (PEEP applied by a ventilator) and intrinsic PEEP (PEEP caused by an incomplete exhalation). Pressure that is applied or increased during an inspiration is termed pressure support.

Intrinsic PEEP (auto)

Auto (intrinsic) PEEP — Incomplete expiration prior to the initiation of the next breath causes progressive air trapping (hyperinflation). This accumulation of air increases alveolar pressure at the end of expiration, which is referred to as auto-PEEP.

Auto-PEEP develops commonly in high minute ventilation (hyperventilation), expiratory flow limitation (obstructed airway) and expiratory resistance (narrow airway).

Once auto-PEEP is identified, steps should be taken to stop or reduce the pressure build-up.[2] When auto-PEEP persists despite management of its underlying cause, applied PEEP may be helpful if the patient has an expiratory flow limitation (obstruction).[3][4]

Extrinsic PEEP (applied)

Applied (extrinsic) PEEP — is usually one of the first ventilator settings chosen when mechanical ventilation is initiated. It is set directly on the ventilator.

A small amount of applied PEEP (4 to 5 cmH2O) is used in most mechanically ventilated patients to mitigate end-expiratory alveolar collapse.[5] A higher level of applied PEEP (>5 cmH2O) is sometimes used to improve hypoxemia or reduce ventilator-associated lung injury in patients with acute lung injury, acute respiratory distress syndrome, or other types of hypoxemic respiratory failure.[6]

Complications

Positive end-expiratory pressure can contribute to:

History

John Scott Inkster an English anaesthetist and physician is credited with discovering PEEP.[10] When his discovery was published in the proceedings of the World Congress of Anaesthesia in 1968, Inkster called it Residual Positive Pressure.

See also

References

  1. "Positive end-expiratory pressure (PEEP)". TheFreeDictionary.com. Citing: Saunders Comprehensive Veterinary Dictionary. 2007.
  2. Caramez, MP; Borges, JB; Tucci, MR; Okamoto, VN; et al. (2005). "Paradoxical responses to positive end-expiratory pressure in patients with airway obstruction during controlled ventilation". Crit Care Med. 33 (7): 1519–28. doi:10.1097/01.CCM.0000168044.98844.30. PMC 2287196Freely accessible. PMID 16003057.
  3. Smith, TC; Marini, JJ (1988). "Impact of PEEP on lung mechanics and work of breathing in severe airflow obstruction". J Appl Physiol. 65 (4): 1488–99. PMID 3053583.
  4. Kondili, E; Alexopoulou, C; Prinianakis, G; Xirouchaki, N; et al. (2004). "Pattern of lung emptying and expiratory resistance in mechanically ventilated patients with chronic obstructive pulmonary disease". Intensive Care Med. 30 (7): 1311–8. doi:10.1007/s00134-004-2255-z. PMID 15054570.
  5. Manzano, F; Fernández-Mondéjar, E; Colmenero, M; Poyatos, ME; et al. (2008). "Positive-end expiratory pressure reduces incidence of ventilator-associated pneumonia in nonhypoxemic patients". Crit Care Med. 36 (8): 2225–31. doi:10.1097/CCM.0b013e31817b8a92. PMID 18664777.
  6. Smith, RA (1988). "Physiologic PEEP". Respir Care. 33: 620.
  7. Frost, EA (1977). "Effects of positive end-expiratory pressure on intracranial pressure and compliance in brain-injured patients". J Neurosurg. 47 (2): 195–200. doi:10.3171/jns.1977.47.2.0195. PMID 327031.
  8. Caricato, A; Conti, G; Della Corte, F; Mancino, A; et al. (March 2005). "Effects of PEEP on the intracranial system of patients with head injury and subarachnoid hemorrhage: The role of respiratory system compliance". The Journal of Trauma and Acute Care Surgery. 58 (3): 571–6. doi:10.1097/01.ta.0000152806.19198.db. PMID 15761353.
  9. Oliven, A; Taitelman, U; Zveibil, F; Bursztein, S (March 1980). "Effect of positive end-expiratory pressure on intrapulmonary shunt at different levels of fractional inspired oxygen". Thorax. 35 (3): 181–5. doi:10.1136/thx.35.3.181. PMC 471250Freely accessible. PMID 6770485.
  10. Craft, Alan (December 13, 2011). "John Scott Inkster". BMJ (obituary). 343: D7517. doi:10.1136/bmj.d7517.
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