| IUPAC name
| Other names
|3D model (Jmol)||Interactive image|
|Molar mass||350.451 g/mol|
|Melting point||<25 °C|
|Boiling point||>290 °C|
|P03AC03 (WHO) QP53AC03 (WHO)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|(what is ?)|
Phenothrin, also called sumithrin and d-phenothrin, is a synthetic pyrethroid that kills adult fleas and ticks. It has also been used to kill head lice in humans. d-Phenothrin is used as a component of aerosol insecticides for domestic use. Phenothrin is often used with methoprene, an insect growth regulator that interrupts the insect's biological life cycle by killing the eggs. Phenothrin is the active agent in the branded product Raid Fly & Wasp Killer.
Phenothrin is primarily used to kill fleas and ticks. It is also used to kill head lice in humans, but studies conducted in Paris, France and the United Kingdom have shown widespread resistance to phenothrin.
It is extremely toxic to bees. An U.S. Environmental Protection Agency (EPA) study found that 0.07 micrograms was enough to kill honey bees. It is also extremely toxic to aquatic life with a study showing concentrations of 0.03 ppb killing mysid shrimp. It has increased risk of liver cancer in rats and mice in long term exposure. It is capable of killing mosquitoes, although remains poisonous to cats and dogs, with seizures and deaths being reported due to poisoning. Specific data on concentrations or exposure is lacking.
The EPA has not assessed its effect on cancer in humans. However, one study performed by the Mt. Sinai School of Medicine links sumithrin with breast cancer; the link made by sumithrin's effect on increasing the expression of a gene responsible for mammary tissue proliferation.
In 2005, the U.S. EPA canceled permission to use phenothrin in several flea and tick products, at the request of the manufacturer, Hartz Mountain Industries. The products were linked to a range of adverse reactions, including hair loss, salivation, tremors, and numerous deaths in cats and kittens. In the short term, the agreement called for new warning labels on the products.
As of March 31, 2006, the sale and distribution of Hartz's phenothrin-containing flea and tick products for cats has been terminated. However, EPA's product cancellation order did not apply to Hartz flea and tick products for dogs, and Hartz continues to produce many of its flea and tick products for dogs.
- "d-Phenothrin". National Pesticide Information Center. Retrieved 2016-02-29.
- JOURNAL OF PESTICIDE REFORM/ SUMMER 2003 • VOL. 23, NO. 2 http://www.pesticide.org/get-the-facts/pesticide-factsheets/factsheets/sumithrin
- Barros, Alfredo Carlos Simões Dornellas de; Sampaio, Marcelo de Castro Moura (2012). "Gynecomastia: physiopathology, evaluation and treatment". Sao Paulo Medical Journal. 130 (3): 187–197. doi:10.1590/S1516-31802012000300009. ISSN 1516-3180.
Reinforcing the evidence suggesting that there is a relationship between chemicals and GM, it is worthwhile mentioning the epidemic onset observed among Haitian refugees in 1981 about four months after arrival in United States detention centers.22 After analyzing all identifiable environmental exposures, it was then found that phenothrin, a multi-insecticide contained in sprays that they had used was the causative agent.23 It is now widely known that phenothrin has antiandrogenic activity.
- Brody, MD, PhD, FACE, Steven A.; Loriaux, MD, D. Lynn (2003). "EPIDEMIC OF GYNECOMASTIA AMONG HAITIAN REFUGEES: EXPOSURE TO AN ENVIRONMENTAL ANTIANDROGEN". Endocrine Practice. 9 (5): 370–375. doi:10.4158/EP.9.5.370. ISSN 1530-891X.
- Phenothrin and s-Methoprene; Product Cancellation Order, US Environmental Protection Agency
- Phenothrin; Amendment to Terminate Use, US Environmental Protection Agency
- See also "dog" in the following EPA ruling: "Insect Growth Regulators: S-Hydroprene (128966), S-Kinoprene (107502), Methoprene (105401), S-Methoprene (105402) Fact Sheet". U.S. Environmental Protection Agency.
- d-Phenothrin general information - National Pesticide Information Center
- Pyrethrins and Pyrethroids Fact Sheet - National Pesticide Information Center
- Pyrethrins and Pyrethroids Pesticide Information Profile - Extension Toxicology Network
- Phenothrin in the Pesticide Properties DataBase (PPDB)