Peroxiredoxin 2

PRDX2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxiredoxin 2
External IDs MGI: 109486 HomoloGene: 21182 GeneCards: PRDX2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

7001

21672

Ensembl

ENSG00000167815

ENSMUSG00000005161

UniProt

P32119

Q61171

RefSeq (mRNA)

NM_181738
NM_005809
NM_181737

NM_011563
NM_001317385

RefSeq (protein)

NP_005800.3

NP_035693.3
NP_001304314.1

Location (UCSC) Chr 19: 12.8 – 12.8 Mb Chr 8: 84.97 – 84.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene.[3][4]

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 0.27 nm (= 2.7 angstroms). Transcript variants encoding distinct isoforms have been identified for this gene.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D (Aug 1995). "Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12". Genomics. 26 (3): 602–6. doi:10.1016/0888-7543(95)80183-M. PMID 7607688.
  4. 1 2 "Entrez Gene: PRDX2 peroxiredoxin 2".

Further reading

  • Yao Y, Taylor M, Davey F, RenY, Aiton J , Coote P, Chen X, Yan SD & Gunn-Moore FJ. (2007). "Interaction of Amyloid binding Alcohol Dehydrogenase/Aβ mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model.". Molecular and Cellular Neuroscience. 35 (2): 377–82. doi:10.1016/j.mcn.2007.03.013. PMID 17490890. 


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