PTP4A1

PTP4A1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
Aliases PTP4A1, HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1, protein tyrosine phosphatase type IVA, member 1
External IDs HomoloGene: 2587 GeneCards: PTP4A1
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

7803

n/a

Ensembl

ENSG00000112245

n/a

UniProt

Q93096

n/a

RefSeq (mRNA)

NM_003463

n/a

RefSeq (protein)

NP_003454.1

n/a

Location (UCSC) Chr 6: 63.52 – 63.58 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.[2][3]

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.[3]

Interactions

PTP4A1 has been shown to interact with ATF7.[4]

References

  1. "Human PubMed Reference:".
  2. Peng Y, Genin A, Spinner NB, Diamond RH, Taub R (Aug 1998). "The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer". J Biol Chem. 273 (27): 17286–95. doi:10.1074/jbc.273.27.17286. PMID 9642300.
  3. 1 2 "Entrez Gene: PTP4A1 protein tyrosine phosphatase type IVA, member 1".
  4. Peters, C S; Liang X; Li S; Kannan S; Peng Y; Taub R; Diamond R H (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. United States. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. ISSN 0021-9258. PMID 11278933.

Further reading


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