PTBP2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CQ1, 2MJU, 4CQ1

Identifiers

Aliases

PTBP2, PTBLP, brPTB, nPTB, polypyrimidine tract binding protein 2

External IDs

MGI: 1860489 HomoloGene: 23162 GeneCards: PTBP2

Gene ontology
Molecular function	• mRNA binding • pre-mRNA binding • nucleotide binding • nucleic acid binding • poly(A) RNA binding • RNA binding
Cellular component	• growth cone • spliceosomal complex • neuronal cell body • nucleus
Biological process	• mRNA splice site selection • cerebellum development • mRNA processing • RNA splicing • spinal cord development • regulation of neural precursor cell proliferation • negative regulation of RNA splicing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


58155


56195

Ensembl


ENSG00000117569


ENSMUSG00000028134

UniProt


Q9UKA9


Q91Z31

RefSeq (mRNA)

NM_001300985 NM_001300986 NM_001300987 NM_001300988 NM_001300989
NM_001300990 NM_021190


NM_019550 NM_001310711

RefSeq (protein)

NP_001287914.1 NP_001287915.1 NP_001287916.1 NP_001287917.1 NP_001287918.1
NP_001287919.1 NP_067013.1


NP_001297640.1 NP_062423.1

Location (UCSC)

Chr 1: 96.72 – 96.82 Mb

Chr 3: 119.72 – 119.78 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.^[3]^[4]

Function

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
1 2 "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia - version of the 6/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.