IUPAC name
4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzene-1,3-disulfonic acid
Other names
149017-66-3 YesY
192575-19-2 (tetrasodium salt) YesY
3D model (Jmol) Interactive image
ChEBI CHEBI:34941 YesY
ChemSpider 20136164
PubChem 6093163
6532796 (tetrasodium salt)
Molar mass 511.37 g·mol−1
Appearance Orange solid
100 mM (tetrasodium salt)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergic P2X antagonist.[2] It is able to block contractions of rabbit vas deferens induced by ATP or α,β,methylene-ATP. It appears to be relatively selective for P2X receptors, having no appreciable activity at α1 adrenergic, muscarinic M2 and M3, histamine H1, and adenosine A1 receptors.[3]


  1. PPADS tetrasodium salt, Santa Cruz Biotechnology
  2. Ziganshin, AU (December 1993). "PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder.". British Journal of Pharmacology. 110 (4): 1491–95. doi:10.1111/j.1476-5381.1993.tb13990.x. PMC 2175839Freely accessible. PMID 8306091.
  3. Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses". European Journal of Pharmacology. 217: 217–19. doi:10.1016/0014-2999(92)90877-7. PMID 1330591.

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