PLA2G4B

JMJD7-PLA2G4B

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1BCI, 1CJY, 1RLW

Identifiers

JMJD7-PLA2G4B, HsT16992, cPLA2-beta, JMJD7-PLA2G4B, PLA2G4B, JMJD7-PLA2G4B readthrough

External IDs

HomoloGene: 130533 GeneCards: JMJD7-PLA2G4B

Gene ontology
Molecular function	• calcium ion binding • phospholipase activity • calcium-dependent phospholipase A2 activity • metal ion binding • calcium-dependent phospholipid binding • hydrolase activity • phospholipase A2 activity • phosphatidylcholine 1-acylhydrolase activity • lysophospholipase activity
Cellular component	• cytoplasm • cytosol • endosome • early endosome membrane • membrane • mitochondrial membrane • extracellular region • mitochondrion • mitochondrial inner membrane
Biological process	• phosphatidic acid biosynthetic process • phosphatidylserine acyl-chain remodeling • phosphatidylethanolamine acyl-chain remodeling • glycerophospholipid catabolic process • lipid metabolic process • lipid catabolic process • IRE1-mediated unfolded protein response • parturition • phosphatidylglycerol acyl-chain remodeling • phospholipid catabolic process • phospholipid metabolic process • metabolic process • inflammatory response • arachidonic acid metabolic process • phosphatidylcholine acyl-chain remodeling • calcium-mediated signaling
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


8681


n/a


ENSG00000168970


n/a


P0C869


n/a

RefSeq (mRNA)


NM_001198588 NM_005090


n/a

RefSeq (protein)


NP_001108105.1 NP_001185517.1 NP_005081.1


n/a

Location (UCSC)

Chr 15: 41.83 – 41.85 Mb

n/a

PubMed search

^[1]

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View/Edit Human

Phospholipase A2, group IVB (cytosolic), also known as PLA2G4B, is a human gene.^[2]

References

Further reading

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
Underwood KW, Song C, Kriz RW, et al. (1998). "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2". J. Biol. Chem. 273 (34): 21926–32. doi:10.1074/jbc.273.34.21926. PMID 9705332.
Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999). "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 274 (13): 8823–31. doi:10.1074/jbc.274.13.8823. PMID 10085124.
Song C, Chang XJ, Bean KM, et al. (1999). "Molecular characterization of cytosolic phospholipase A2-beta". J. Biol. Chem. 274 (24): 17063–7. doi:10.1074/jbc.274.24.17063. PMID 10358058.
Degousee N, Ghomashchi F, Stefanski E, et al. (2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis". J. Biol. Chem. 277 (7): 5061–73. doi:10.1074/jbc.M109083200. PMID 11741884.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ghosh M, Loper R, Gelb MH, Leslie CC (2006). "Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes". J. Biol. Chem. 281 (24): 16615–24. doi:10.1074/jbc.M601770200. PMID 16617059.

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