PDCD4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2KZT, 2GGF, 2RG8, 2ZU6, 3EIJ

Identifiers

Aliases

PDCD4, H731, programmed cell death 4 (neoplastic transformation inhibitor)

External IDs

MGI: 107490 HomoloGene: 7879 GeneCards: PDCD4

Gene ontology
Molecular function	• protein binding • RNA binding
Cellular component	• cytoplasm • cytosol • nucleus • nucleoplasm
Biological process	• cell aging • regulation of protein metabolic process • negative regulation of cell cycle • negative regulation of apoptotic process • negative regulation of transcription, DNA-templated • negative regulation of JUN kinase activity • positive regulation of smooth muscle cell apoptotic process • negative regulation of myofibroblast differentiation • apoptotic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


27250


18569

Ensembl


ENSG00000150593


ENSMUSG00000024975

UniProt


Q53EL6 Q5VZS7


Q61823

RefSeq (mRNA)


NM_145341 NM_001199492 NM_014456


NM_001168491 NM_001168492 NM_011050

RefSeq (protein)


NP_055271.2 NP_663314.1


NP_001161963.1 NP_001161964.1 NP_035180.2

Location (UCSC)

Chr 10: 110.87 – 110.9 Mb

Chr 19: 53.89 – 53.93 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.^[3]^[4] It is one of the targets of an oncomiR, MIRN21.^[5]

Function

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.^[4]

Interactions

PDCD4 has been shown to interact with RPS13^[6] and Ribosomal protein L5.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of immunology. 161 (7): 3493–500. PMID 9759869.
1 2 EntrezGene 27250
↑ Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008). "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of Biological Chemistry. 283 (2): 1026–33. doi:10.1074/jbc.M707224200. PMID 17991735.
1 2 Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.

Göke R, Gregel C, Göke A, Arnold R, Schmidt H, Lankat-Buttgereit B (2004). "Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells". Annals of the New York Academy of Sciences. 1014: 220–1. doi:10.1196/annals.1294.024. PMID 15153438.
Maruyama K, Sugano S (1994). "Oligo-capping: A simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Shibahara K, Asano M, Ishida Y, Aoki T, Koike T, Honjo T (1995). "Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death". Gene. 166 (2): 297–301. doi:10.1016/0378-1119(95)00607-9. PMID 8543179.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z (1999). "Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody". Pathology International. 49 (12): 1067–77. doi:10.1046/j.1440-1827.1999.00995.x. PMID 10632927.
Soejima, H.; Miyoshi, O.; Yoshinaga, H.; Masaki, Z.; Ozaki, I.; Kajiwara, S.; Niikawa, N.; Matsuhashi, S.; Mukai, T. (1999). "Assignment¹ of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization". Cytogenetic and Genome Research. 87: 113–4. doi:10.1159/000015408.
Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
Chen Y, Knösel T, Kristiansen G, Pietas A, Garber ME, Matsuhashi S, Ozaki I, Petersen I (2003). "Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis". The Journal of Pathology. 200 (5): 640–6. doi:10.1002/path.1378. PMID 12898601.
Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH (2004). "A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A". Molecular and Cellular Biology. 24 (9): 3894–906. doi:10.1128/MCB.24.9.3894-3906.2004. PMC 387765. PMID 15082783.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust Phosphoproteomic Profiling of Tyrosine Phosphorylation Sites from Human T Cells Using Immobilized Metal Affinity Chromatography and Tandem Mass Spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Göke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B (2004). "Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21Waf1/Cip1". AJP: Cell Physiology. 287 (6): C1541–6. doi:10.1152/ajpcell.00025.2004. PMID 15317660.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2004). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y (2005). "Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein". Cancer Research. 65 (24): 11282–6. doi:10.1158/0008-5472.CAN-05-3469. PMID 16357133.
Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH (2006). "Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion". Molecular and Cellular Biology. 26 (4): 1297–306. doi:10.1128/MCB.26.4.1297-1306.2006. PMC 1367180. PMID 16449643.

PDB gallery

2ggf: Solution structure of the MA3 domain of human Programmed cell death 4

2hm8: Solution Structure of the C-terminal MA-3 domain of Pdcd4

2iol: Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 1

2ion: Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2

2ios: Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 3

2nsz: 1.15 Angstrom Crystal Structure of the MA3 domain of Pdcd4

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PDCD4

Function

Interactions

References

Further reading